Traditional drug-loaded nanofibers face challenges such as unstable drug loading and excessively rapid release.In light of these issues,this study employs a thermosensitive copolymer(P(NIPAM-co-AM))to coat hollow mesoporous silica nanoparticles(HMSN),incorporating them as drug carriers in conjunction with poly(e-caprolac-tone)(PCL)nanofibers.The drug release and antibacterial performance of the composite nanofiber membrane were investigated.Firstly,the HMSN surface was functionalized through free radical polymerization by grafting a copolymer of isopropylacrylamide(NIPAM)and acrylamide(AM)(P(NIPAM-co-AM)).Hydrophobic drug cipro-floxacin(CIP)was loaded into the modified nanoparticles(P(NIPAM-co-AM)-HMSN or PHMSN).The analysis of the microstructure,composition,and temperature-responsibility of the drug-loaded particles were performed us-ing SEM,TEM,TG,BET analysis,FTIR,UV-Vis spectroscopy,etc.Blending PCL with drug-loaded PHMSN,a com-posite fibrous membrane(CIP@PHMSN-PCL)was fabricated using electrospinning.CIP@PHMSN-PCL exhibited temperature-stimulated drug releasing,with cumulative release rates of CIP reaching 90.78％and 72.67％at 45℃and 25℃ after 72 h,respectively.The Korsmeyer-Peppas model apply described the drug release kinetics,suggest-ing the diffusion as the primary mechanisms for drug release from the composite fiber membrane.At 45℃,the drug-loaded fiber membrane exhibited a 100％inhibition rate against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).At 25℃,the inhibition rates were 92.34％and 95.83％against E.coli and S.aureus,respectively,demon-strating temperature-dependent drug release performance of the CIP@PHMSN-PCL membrane.In summary,the drug-loaded PHMSN composite nanofiber membrane exhibits temperature-regulated drug release functionality and excellent antibacterial activity,holding potential application value in the biomedical field.
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