多孔材料ZIF-8的制备及其对布洛芬的载药性能
Preparation of the porous ZIF-8 and the behaviors of loading ibuprofen
孙瑞华 1杨卓凡 2张芮博 1江奇 2卢晓英 3廖海1
作者信息
- 1. 西南交通大学生命科学与工程学院,成都 610031
- 2. 磁浮技术与磁浮列车教育部重点实验室,成都 610031
- 3. 西南交通大学医学院(生物医学工程研究院),成都 610031
- 折叠
摘要
难溶性药物的低溶解度,严重限制了其口服生物利用度.对此,结合金属-有机框架(MOFs)材料具有疏水性和高比表面积的特点,以溶液共沉淀法制备了MOF多孔材料ZIF-8作为载药基底.通过改变Zn2+与 2-甲基咪唑(2-methylimidazole)的摩尔比,进而对ZIF-8的比表面积及孔径分布进行调控,然后对难溶性药物布洛芬(IBP)的负载性能进行研究.研究结果表明:当Zn2+与 2-甲基咪唑的摩尔比为 1∶8时,材料ZIF-8(8)具有最大的比表面积和孔体积,分别为 1 187 m2/g和 1.183 cm3/g,其对难溶性药物布洛芬的负载量高达21.8％.且药物载体复合材料IBP-ZIF-8(8)表现出良好的体外溶出度,在pH为 2.5和 7.4的磷酸缓冲溶液中,其累积溶出度均为 98％左右.ZIF-8(8)处理的小鼠单核巨噬细胞白血病细胞(Mouse mononuclear macrophages cells,RAW246.7)存活率均高达94％以上,表现出良好的生物安全性.
Abstract
Oral bioavailability of poorly soluble drugs is severely limited due to their low solubility.In recent years,metal-organic frameworks(MOFs)materials have attracted much attention because of their hydrophobicity and high specific surface area.In this paper,the porous ZIF-8,one of MOF family materials,were prepared by solution co-precipitation method.The specific surface area and pore size distribution of ZIF-8 were optimized by changing the molar ratio of Zn2+to 2-methylimidazole.In addition,ZIF-8 were used as the carrier for ibuprofen(IBP),a poorly soluble drug,and its loading performance was studied in detail.The results showed that when the molar ratio of Zn2+to 2-methylimidazole was 1∶8,ZIF-8(8)had the largest specific surface area(1 187 m2/g)and pore volume(1.183 cm3/g).And the loading capacity of ZIF-8(8)on IBP was as high as 21.8％.The drug carrier composite(IBP-ZIF-8(8))showed a well dissolution rate in vitro,and its cumulative dissolution rate was about 98％in phosphate buffer solution with pH of 2.5 and 7.4.The survival rate of RAW246.7 cells treated with IBP-ZIF-8(8)was over 94％,demonstrating satisfied biosafety.ZIF-8(8)with excellent specific surface area,pore volume,good loaded-IBP per-formance and biosafety has great potential applications in drug controlled-release system.
关键词
有机-金属框架物/ZIF-8/布洛芬/难溶性药物/口服生物利用度Key words
metal-organic frameworks/ZIF-8/ibuprofen/poorly soluble drugs/oral bioavailability引用本文复制引用
出版年
2024
NETL
NSTL
万方数据