Research Progress on Metabolic Engineering of Yeast for Monoterpenoids Synthesis
Monoterpenoids are a class of compounds with a molecular structure consisting of two isoprene units,containing a total of 10 carbon atoms.They are commonly found in the secretory tis-sues of higher plants.Their oxygenated derivatives,such as alcohols,aldehydes,and ketones,exhibit high biological activity and are frequently used to produce preservatives,deodorants,disin-fectants,and other products.Traditionally,monoterpenoids have been obtained through natural product extraction and chemical synthesis.However,with the continuous innovation and develop-ment of synthetic biology technology,the use of microorganisms as metabolic factories for production has become an inevitable trend,offering advantages such as low cost,high controllability,and sig-nificant potential for scalability.This review summarizes the research progress in the production of monoterpenoids using yeast as a chassis,focusing on three aspects:metabolic pathway engineering,enzyme engineering,and cell engineering,demonstrating the applicability and effectiveness of met-abolic engineering transformation methods for the production of natural active products in microorgan-isms.
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