Progress in the Study of the Mechanism by Which Bacteria Hydrolyze of NAD+to Defend Against Bacteriophage Infection
Over the course of long-term evolution,bacteria have employed CRISPR-Cas systems,restriction-modification,and other immune systems to combat phage infections.In recent years,dozens of novel anti-phage systems have been identified,with a common mechanism that induces the death or metabolic stasis of infected cells through highly diverse ways,thereby preven-ting the further amplification of phages.Current studies have shown that phage infection can activate effector proteins with NAD+hydrolase function,triggering rapid hydrolysis of NAD+.This review summarizes the molecular mechanisms of newly discovered effector proteins that hydrolyze NAD+to exert anti-phage invasion effects,providing theoretical basis and new perspectives for the prevention and control of pathogenic bacteria and the development of efficient phage preparations.
国家科技期刊平台
NSTL
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