细菌水解NAD+抵御噬菌体感染的机制研究进展
Progress in the Study of the Mechanism by Which Bacteria Hydrolyze of NAD+to Defend Against Bacteriophage Infection
吴书娴 1张丹丹 1甄向凯1
作者信息
- 1. 福建师范大学生命科学学院,福建 福州 350117
- 折叠
摘要
在长期的进化过程中,细菌利用CRISPR-Cas系统、限制-修复等免疫系统对抗噬菌体的感染.近年几十个新颖的抗噬菌体系统被发现,其普遍机制为通过极其多样的方式使被感染的细胞死亡或代谢停滞,以阻止噬菌体的进一步扩增.目前研究表明,噬菌体的感染能激活具有NAD+水解酶功能的效应蛋白,触发NAD+的快速水解.并总结了新发现的水解NAD+发挥抗噬菌体入侵的效应蛋白的分子机制,为病原菌的防治以及开发高效噬菌体制剂提供理论和新视角.
Abstract
Over the course of long-term evolution,bacteria have employed CRISPR-Cas systems,restriction-modification,and other immune systems to combat phage infections.In recent years,dozens of novel anti-phage systems have been identified,with a common mechanism that induces the death or metabolic stasis of infected cells through highly diverse ways,thereby preven-ting the further amplification of phages.Current studies have shown that phage infection can activate effector proteins with NAD+hydrolase function,triggering rapid hydrolysis of NAD+.This review summarizes the molecular mechanisms of newly discovered effector proteins that hydrolyze NAD+to exert anti-phage invasion effects,providing theoretical basis and new perspectives for the prevention and control of pathogenic bacteria and the development of efficient phage preparations.
关键词
NAD+/NAD+水解酶/抗噬菌体/毒素/流产感染Key words
NAD+/NAD+hydrolase/phage resistance/toxin/abortive infection引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据