This study was conducted to investigate the effects of high reducing dietary crude protein level and supplement with argi-nine on the growth performance,blood antioxidant and immune indicators of weaned piglets.One hundred and twenty eight crossbred piglets(Duroc×Landrace×Large White)were selected and randomly divided into four treatments,each treatment had 4 replicates and each replicate had 8 piglets.The control group was fed a basal diet(CP is 15.98%);The experimental group 1,2 and 3 were supple-mented with 0.4%,0.8%and 1.2%arginine in the basal diet,respectively.The experiment lasted for 16 days.The results showed as follows:Compared with control group,1)The average daily weight gain(ADG)in experimental group 1 and 2 was extremely significant-ly increased(P<0.05),the feed to gain(F/G)in experimental group 2 was significantly lower(P<0.05),the diarrhea rate in experimental group 1,2 and 3 was significantly decreased(P<0.05).2)The blood T-AOC concentrations in experimental group 1 and 2 were signifi-cantly increased(P<0.05),the GSH-PX activity in experimental group 1,2 and 3 were significantly increased(P<0.05),the blood MDA concentrations in experimental group 1 and 2 were significantly decreased(P<0.05).3)The concentrations of IgA and IgG in experi-mental group 1,2 and 3 were significantly increased(P<0.05).In conclusion,the diet of high reducing dietary crude protein level and supplemented with moderate amount of arginine(0.8%)in weaning piglets could improve the ADG,decrease the feed to gain ratio,re-duce diarrhea,and improve antioxidant capacity and immune function.