餐后高血糖对2型糖尿病血管病变的影响
Postprandial Hyperglycemia and the Vasculopathy in Patients with Diabetes Mellitus
方志平 1孙旭东2
作者信息
- 1. 福建医科大学附属协和医院内分泌科,福州,350001
- 2. 福建医科大学附属协和医院心脏彩超室,福州,350001
- 折叠
摘要
目的 探讨餐后高血糖对2型糖尿病血管病变的影响.方法 收集120例2型糖尿病患者的临床资料,包括年龄、性别、血压、体质量指数(BMI)、血脂、空腹血糖、3餐后2 h血糖、糖基化血红蛋白(HbA1c)、眼底性状、尿微白蛋白、心彩超、颅脑 CT、心电图等.并与60名健康体检者(对照组)进行比较.人选者均行颈部血管彩超检查测平均颈动脉内-中膜厚度(C-IMT).结果 (1)C-IMT值在2型糖尿病组明显高于对照组;有并发症组明显高于无并发症组.餐后2 h血糖均值分布梯度与之一致.(2)相关性研究显示,C-IMT值与餐后2 h血糖均值存在显著正相关,C-IMT及餐后2 h血糖均值与糖尿病血管并发症发生率亦均呈显著正相关.结论 餐后高血糖为2型糖尿病血管病变的独立危险因素.
Abstract
Objective To study Effects of postprandial hyperglycemia on the vasculopathy of patients with diabetes mellitus. Methods Collect clinical datas of 120 patients with diabetes mellitus, included age, sex, blood pressure, body mass index(BMI), blood fat, fasting plasma glucose, glycosylated hemoglobin(GHb), eyeground character, and electrocardiogram and so on. Comparison with 60 healthy examination persons(control group). Carotid intra-tunica media of all persons were measured. Results (1)Carotid intra-tunica media of patients of diabetes mellitus with complication higher than no complication. It was higher in patients of diabetes mellitus than control group too. (2)Carotid artery intima-media thickness(C-IMT) positive correlation to 2 h postprandial hyperglycemia, C-IMT and postprandial hyperglycemia all positive correlation to incidence of vasculopathy. Conclusion postprandial hyperglycemia is independence risk factor of vasculopathy of patients with diabetes mellitus.
关键词
糖尿病血管病变/糖尿病,2型/血糖,饭后期间/动脉硬化/颈动脉Key words
diabetic angiopathies/diabetes mellitus,type 2/blood glucose/postprandial period/arteriosclerosis/microangiopathy/carotia arteries引用本文复制引用
出版年
2008
NETL
NSTL
维普
万方数据