Correlation Analysis of Platelet-Albumin-Bilirubin Scores and Child-Turcotte-Pugh Grade Liver Function in Patients with Cirrhosis
Objective To analyze the correlation between platelet-albumin-bilirubin (PALBI)scores and Child-Turcotte-Pugh (CTP)grade of liver function in cirrhotic patients. Methods A total of 237 cirrhotic hospitalized patients and 89 healthy controls during the same period were enrolled. The cirrhotic patients were divided into grades A,B and C according to CTP grade. According to PALBI scores level,the patients were divided into low PALBI scores group (118 cases)and high PALBI scores group (119 cases). The correlation between PALBI scores,other scoring systems and CTP scores was analyzed,as well as the correlations between other scoring systems and PALBI scores. The diagnostic efficiency of each scoring system for different grades of cirrhosis was tested by receiver operating characteristic (ROC) curve. Results The higher the CTP grade,the higher the PALBI scores in cirrhotic patients (grade C >grade B > grade A > control). PALBI scores,aspartate aminotransferase to platelet ratio index (APRI),fibrosis 4 score (FIB-4)and model for end-stage liver disease (MELD)scores were positively correlated with CTP scores (r=0.766,0.423,0.552,0.538,P<0.001),and the correlation between PALBI scores and CTP scores was better than that between APRI,FIB-4 and MELD scores. The area under the ROC curve of PALBI scores predicting cirrhosis grades A,B and C were higher than APRI, FIB-4 and MELD scores. Conclusions The PALBI scores was significantly and positively correlated with the CTP grade of cirrhosis,which helped to assess the severity of cirrhosis in patients.
万方数据
维普
