Assessment of the Prognostic Value of PD-L1 Expression in Circulating Tumor Cells in Patients with Nasopharyngeal Carcinoma
Objective To explore the prognostic value of programmed cell death-ligand 1 (PD-L1) expression on circulating tumor cells (CTC)in patients with nasopharyngeal carcinoma. Methods A ret-rospective analysis of 59 patients with nasopharyngeal carcinoma diagnosed by pathological examination from June 10,2021 to July 10,2023 were performed. The expression of CTC and PD-L1 in peripheral blood of the patients was detected. The correlation between CTC and PD-L1+ CTC and clinicopathological features of nasopharyngeal cancer patients was analyzed;the clinical diagnostic value of CTC and PD-L1+ CTC detection on the prognosis of nasopharyngeal cancer patients was evaluated. Results Patients with naso-pharyngeal carcinoma had a 76.3％ CTC detection rate (45/59),and there were (1.4±1.1)CTC found. There was a significant difference between the CTC number among different M stage (P=0.026). The detection rate of PD-L1+ CTC was 35.6％ (21/59),and the number of detections was (0.4±0.7). Nasopharyngeal carcinoma patients had a 2-year disease progression rate of 8.47％ (5/59),and patients with PD-L1+ CTC had lower progression-free survival (PFS)and overall survival (OS)compared with PD-L1- CTC patients,both of which were statistically significant different (P=0.016,P=0.012). Cox regression analysis showed that PD-L1+ CTC was an prognostic influencing factor for PFS (HR=9.244, 95％CI:1.030-82.991,P=0.047)and OS (HR=190.642,95％CI:1.389-341.562,P=0.023)in nasopha-ryngeal carcinoma patients. Conclusion PD-L1+ CTC was an prognostic influencing factor for PFS and OS in nasopharyngeal carcinoma patients. CTC and PD-L1 expression could facilitate assisting prognosis evaluation for patients with nasopharyngeal carcinoma.
万方数据
维普
