Analysis of Maternal Serum Placental Growth Factor and Second-trimester Down's Syndrome Screening to Predict Fetal Growth Restriction
Objective It is to assess the predictive value of placental growth factor (PlGF)in com-bination with second-trimester Down's syndrome screening for fetal growth restriction (FGR). Method 530 pregnant women with singleton pregnancies who visited our hospital from June 2020 to January 2022 were collected,and blood was collected at 15-20+6 weeks of gestation for PlGF and econd-trimester Down's screening;linear correlation analysis and binary logistic analysis were performed for each indicator,and the performance of the model was assessed using the subject's work characteristic curve (ROC). Results The correlation between the three serum biomarkers of second-trimester Down's screening and PlGF was not statistically significant (P>0.05). The ROC curve suggested that higher diagnostic efficacy could be achieved by combining PlGF and midterm Down's screening (P=0.009),with an area under the curve (AUC)of 0.873 (95％CI:0.787-0.959 ),a sensitivity of 76.0％ and a specificity was 93.2％. Conclusion The addition of PlGF to the second-trimester Down's syndrome screening in the established obstetrics program has clinical significance in the prediction of FGR.
second-trimester Down's syndrome screeningfetal growth restrictionplacental growth factorpredictive model
万方数据
维普
