Low-Fluence Q-switched Nd∶YAG Laser Combined with Microneedle Introduction of Tranexamic Acid for Melasma Treatment
Objective To evaluate the therapeutic efficacy of low-fluence Q-switched Nd∶YAG(QSNY)laser monotherapy versus the combined therapy of QSNY laser with microneedle-assisted tranex-amic acid for melasma,while employing dermoscopy to discern the most favorable treatment for melasma subtypes.Methods The clinical data of patients diagnosed with chloasma from January 2022 to Decem-ber 2023 were collected.The modified melasma area and severity index(mM ASI)score,total dermosco-py score(TDS),physician clinical assessment(PGA)and the incidence of adverse reactions were compared between the patients in QSNY laser monotreatment group(control group,23 cases)and the combined therapy group of QSNY laser with microneedle-assisted tranexamic acid(combined group,23 cases)after 3 times of treatment.Results The mMASI scores of patients in both groups were reduced after treatments,while the improvement of mMASI scores in the combined group exhibitied a significantly greanter increase(P＜0.05).TDS was reduced after treatment in both groups,while the improvement extent of the combined group was better,the difference was statistically significant(P＜0.05).Compared with the pre-treatment,capillary dilatation signifcantly decreased in the combined group(P＜0.001).The intergroup difference of PGA score between the two groups was not statistically significant(P＞0.05),and no significant adverse reactions were found in either groups.Conclusion The efficacy of QSNY laser with microneedle-assisted tranexamic acid combined therapy to melasma is greater than that of QSNY laser monotreatment to melasma.The combined therapy is more favorable to melas-ma with obvious vascular proliferation and epidermal pigmentation.
万方数据
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