Analysis of Clinical Characteristics of Human Metapneumovirus Infection Patients in 878 Cases of Hospitalized Children with Community-Acquired Pneumonia in Yinchuan City
Objective To investigate epidemiological and clinical characteristics of human metap-neumovirus(HMPV)in 878 hospitalized children with community-acquired pneumonia(CAP)in Yinchuan City.Methods A total of 878 hospitalized children with CAP in Yinchuan Women and Children Health-care Hospital were observed from January 2018 to December 2019.Specimens of lower respiratory tract secretions were collected and tested for 15 common respiratory viruses including HMPV,respiratory syn-cytial virus(RSV),human coronavirus(HCoV)229E/NL63,adenovirus(AdV),parainfluenza virus(PIV)types 1,2 and 3,human bocavirus(HBoV)and other viruses by multiplex PCR analysis.The ep-idemiological data,clinical manifestations and laboratory tests of HMPV-positive cases were retrospectively analyzed.Results Of the 878 hospitalized children with CAP,140 cases(15.95％)were positive for HMPV,of which 32 cases(22.86％)were positive for single HMPV infection,71 cases(50.71％)were co-infected with other viruses,8 cases(5.71％)were co-infected with bacteria,24 cases(17.14％)were infected together with other viruses and bacteria,and 5 cases(3.58％)were positive for mycoplasma anti-body test.The main types of other viruses co-infected with HMPV were HRV,PIV3 and RSV,and the main types of co-infected bacteria were Klebsiella pneumoniae,Escherichia coli and Streptococcus pneu-moniae.HMPV infection had high incidence in spring and summer and its infection was mainly in the children of 5 years old or below.Among the 49 severe CAP cases,7 cases(14.29％)were positive for HMPV,all of whom were co-infected with other viruses and bacteria.The main clinical manifestations included cough,fever and pharyngeal congestion.Compared with patients infected with other pathogens,patients with single HMPV positivity had lower white blood cell(WBC)counts(P＜0.05),and the WBC counts and creatinine(Cr)levels of HMPV positive children with severe CAP were lower than those of HMPV-negative patients,with statistically significant differences(P＜0.01,P＜0.05).There was no statistically significant difference in other clinical symptoms and related indicators(P＞0.05).Conclusions HMPV is one of the common pathogens causing CAP in children in Yinchuan City,and it is often infected together with other pathogenic microorganisms.Children of 5 years old or below are sus-ceptible to HMPV infection,which easily occurs in spring and summer.
human metapneumoviruscommunity-acquired pneumoniachildreninfectionYinchuan City
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