Effect of Oxycodone Patient-Controlled Intravenous Analgesia on Immune Function and Analgesic Efficacy in Postoperative Lung Cancer Patients
Objective It is to study the effects of oxycodone used for patient-controlled intrave-nous analgesia(PCIA)on the immune function in postoperative lung cancer patients.Methods This study was a single-center,prospective,randomized,controlled,double-blind trial.A total of 120 patients undergoing thoracoscopic lobectomy were randomly assigned to the oxycodone group(OC group)or the sufentanil group(SF group).Both groups used the same anesthesia technique and postoperative PCIA without a background dose:OC group received 100 mg oxycodone hydrochloride and 25 mg ondanse-tron;SF group received 100 pg sufentanil and 25 mg ondansetron.Both drugs were diluted to 100 mL in saline in the 2 groups,respectively.The analgesic pump dose was set as follows:The initial dose was 10 mL,Bolus dose was 4 mL,with a lockout interval of 5 min and no background infusion.Primary outcome measures included the percentages of whole blood CD4+and CD8+T lymphocytes and NK cells in patients at 24 hours preoperatively(T0)and at 6 hours(T1),12 hours(T2),24 hours(T3),and 48 hours(T4)postoperatively.Secondary outcome measures included Ramsay sedation scores,static and dynamic visual analog scores(VAS)pain scores at each time point from T1 to T4,number of analgesic pump pres-ses at T4,number of analgesic remedial drug use,adverse reactions,postoperative chest drainage retention time,and hospitalization stay.Results At T1,T2,and T3,the percentages of CD4+and CD8+T cells were significantly higher in the OC group than those in the SF group.At T4,the percentage of CD4+T cells was significantly higher that in the OC group(P＜0.05).At T1,T2,and T3,the percentages of NK cells were significantly higher in the OC group than those in the SF group(P＜0.05).The SF group had significantly more analgesic pump presses than the OC group at T4(P＜0.05).There were no signif-icant differences in Ramsay scores,static and dynamic VAS scores,or complications at various time points between the two groups(P＞0.05).Conclusion Both oxycodone and sufentanil used for postoperative PCIA in lung cancer patients suppress immune function;however,oxycodone has a milder suppressive effect and provides better analgesia,making it more suitable for PCIA after lung cancer surgery.
oxycodonesufentanilpostoperative analgesialung cancerimmune function
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