Construction of a Novel Prognostic Model Based on Disulfidptosis-Related lncRNA for Elderly Hepatocellular Carcinoma
Objective This study aims to explore a new prognostic model of disulfidptosis-related lncRNA(DRLS)in elderly hepatocellular carcinoma(HCC)patients and validate its application in evalua-ting patient prognosis and guiding treatment choices.Methods Transcriptome data,clinical informa-tion,and mutation details of the cancer genome atlas liver hepatocellular carcinoma(TCGA-LIHC)were downloaded from TCGA.DRLS were screened and categorized into elderly and young groups.Venn di-agrams were used to exclude lncRNAs affecting young group HCC,retaining only those impacting the eld-erly group.A prognostic model related to DRLS was constructed using Cox regression and the least ab-solute ahrinkage and aelection operator(LASSO)analysis.Differences in prognosis,biological func-tions,mutation landscapes,and drug sensitivities between high-risk and low-risk groups in elderly HCC patients were assessed.Results Using LASSO and Cox regression methods,this study established DRLS and divided patients into low-risk and high-risk groups.This study showed that patients in the low-risk group had significantly higher overall survival(OS)and progression-free survival(PFS)than those in the high-risk group,and a clinically relevant nomogram was developed.Differential gene expres-sion enrichment analysis revealed significant enrichment of these genes in cell cycle,superoxide produced by nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activity,cell division,cytoskeletal movement,and related metabolic activities.The low-risk group had lower scores for tumor immune dys-function and exclusion(TIDE).In drug sensitivity analysis,the low-risk group showed higher sensitivity to sorafenib,oxaliplatin,and irinotecan,while the high-risk group was more sensitive to 5-fluorouracil,MIRA-1,and staurosporine.Overall,elderly HCC patients in the low-risk group had better prognosis,lower mutation rates,better response to immunotherapy,and higher sensitivity to anti-tumor drugs.Conclusion DRLS effectively predicts the prognosis of elderly HCC patients and is closely related to their biological functions,mutation genes,and drug sensitivities,providing new insights for further exploring the relationship between disulfidptosis and HCC.
disulfidptosiselderlyhepatocellular carcinomalncRNAprognostic model
万方数据
维普
