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光疗在脑功能调控康复中的应用

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视网膜感光神经节细胞的发现开辟了一个全新的研究领域:光的非成像视觉功能.环境中的光对特定脑功能会产生广泛的影响.光作为一种重要的物理因子治疗方法,具有非侵入性、安全有效、成本低、毒副作用小、依从性高等特点,在耐受性和安全性方面具有明显优势,光疗在脑功能调控康复领域具有重要的临床价值.本研究系统梳理了光疗在情感障碍、认知功能障碍、睡眠障碍及疼痛领域康复中的应用,研究结果支持光疗对多种与大脑功能相关的疾病具有一定正向调节作用.但光疗在脑功能调控中的应用仍处于初步阶段,还存在一些不足之处,如光疗具体作用机制有待进一步阐明;较少开展光疗联合其他疗法的研究;光疗的长期临床效应有待观察.下一步研究还需解析光疗的神经机制,探讨建立靶向特定环路、高效调节脑功能的新型光疗范式;在传统康复治疗的基础上探讨光疗是否可以产生附加康复效应;加强光疗临床应用的长期随访,观察光疗是否具有长期效应,为光疗在脑功能调控的应用提供参考.
Application of Light Therapy in Brain Function Modulation and Rehabilitation
The discovery of intrinsically photosensitive retinal ganglion cells(ipRGCs)has opened up a new field of research:the non-image forming visual(NIFV)of light.Light in the environment can have extensive effects on specific brain functions.As an important physical modality treatment method,light therapy is a novel intervention that has several strengths:non-invasive,safe,ef-fective,low-cost,few adverse effects,and high compliance.It has clear advantages in terms of tolerance and safety.Light therapy has significant clinical values in the rehabilitation field of brain function modulation.This study systematically reviews the applica-tion of light therapy in the rehabilitation of mood disorders,cognitive dysfunction,sleep disorders,and pain.The results support that light therapy exerts a positive regulatory effect on various diseases related to brain function.However,the application of light thera-py in brain function modulation is still in its early stage and there are several limitations.For example,the specific mechanisms of light therapy need to be further clarified,there is a lack of research on the combined use of light therapy with other treatments,and the long-term clinical effects remain to be observed.Future research should focus on analyzing the neural mechanisms of light thera-py,establishing new intervention paradigms that target specific neural circuits and efficiently modulate brain function,and exploring whether light therapy can produce additional rehabilitative outcomes when combined with traditional treatments.Additionally,long-term follow-up studies are needed to observe the lasting effects of light therapy and to provide valuable insights for its application in brain function modulation.

light therapybrain function modulationmood disordercognitionsleeppain

陶倩、苏国辉

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暨南大学基础医学与公共卫生学院,广东 广州 510632

暨南大学粤港澳中枢神经再生研究院,广东 广州 510632

光疗 脑功能调控 情绪障碍 认知 睡眠 疼痛

国家自然科学基金项目

82172530

2024

康复学报
福建中医药大学

康复学报

CSTPCD
影响因子:0.545
ISSN:2096-0328
年,卷(期):2024.34(4)
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