物理治疗调控脊髓损伤后小胶质细胞研究进展
Review on Regulation of Microglia after Spinal Cord Injury through Physical Therapy
翟晨元 1伍琦 2蔡吉利 3王钰 3王尊 3方露 3王彤3
作者信息
- 1. 南京医科大学附属苏州医院(苏州市立医院),江苏 苏州 215008;南京医科大学第一附属医院康复医学中心,江苏 南京 210029
- 2. 南华大学第一附属医院,湖南 衡阳 421001
- 3. 南京医科大学第一附属医院康复医学中心,江苏 南京 210029
- 折叠
摘要
脊髓损伤(SCI)是由创伤、肿瘤或炎症等因素导致脊髓完整性和连续性破坏,进而引发严重的感觉、运动及自主神经功能障碍.小胶质细胞作为中枢神经系统的固有免疫细胞,在SCI中发挥着至关重要的作用,并且是SCI后时空变化最显著的细胞群.因此,阐明SCI后小胶质细胞的时空变化,对寻找有效的SCI干预策略具有重要意义.近年来,通过物理治疗调控小胶质细胞的功能及状态以促进SCI功能恢复的研究逐渐增多.本文综述了SCI后小胶质细胞的时空变化及物理治疗调控小胶质细胞的研究进展,旨在为物理治疗改善SCI功能提供更有效的治疗策略.
Abstract
Spinal cord injury(SCI)is a devastating central nervous system condition caused by factors such as trauma,tumors,or inflammation that lead to the destruction of the integrity and continuity of the spinal cord,resulting in severe sensory,motor,and autonomic dysfunction.Microglia,as inherent immune cells in the central nervous system,play an extremely important role in neu-roimmune responses after SCI and are the most significantly changing cell population in terms of space and time after SCI.There-fore,clarifying the spatiotemporal changes of microglia after spinal cord injury has great significance for finding effective interven-tion strategies for spinal cord injury rehabilitation.In recent years,studies on regulating the function and state of microglia through physiotherapy to promote functional recovery after SCI have been gradually increasing.This paper reviews the spatial and temporal changes of microglia after SCI and the research progress of physiotherapy in regulating microglia,aiming to provide a more effec-tive therapeutic strategy for physiotherapy to improve the function of SCI.
关键词
脊髓损伤/小胶质细胞/神经炎症/物理治疗/神经调控Key words
spinal cord injury/microglia/neuroinflammation/physical therapy/neuroregulation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据