Pathogenesis and Rehabilitation Therapy of Aging-Related Cognitive Impairment
The incidence of aging-related cognitive impairment has been increasing year by year with the increase of the aver-age life expectancy of the global population,which seriously affects the daily quality of life and mental health of the elderly,and has become a clinical hotspot of wide social concern.This study summarized the definition,risk factors,pathogenesis,diagnosis,rehabil-itation assessment and rehabilitation treatment methods of aging-related cognitive impairment,in order to provide a theoretical basis for early diagnosis and precise prevention and treatment of aging-related cognitive impairment.Among them,the pathogenesis of aging-related cognitive impairment mainly includes oxidative stress,synaptic plasticity,epigenetic modification and chronic inflam-mation.Rehabilitation assessment mainly includes neuropsychological assessment[Mini-Mental State Examination(MMSE),Mon-treal Cognitive Assessment(MoCA),Wechsler Memory Scale(WMS)and Loewenstein occupational therapy cognitive assessment(LOTCA)],electrophysiological and neuroimaging examination[electroencephalogram(EEG),functional magnetic resonance imag-ing(fMRI)and magnetic resonance spectroscopy(MRS)].Rehabilitation treatment methods mainly include drug therapy(acetylcho-linesterase inhibitors and N-methyl-D-aspartate receptor antagonists)and non-drug therapy[cognitive training,exercise training,multimodal cognitive training,traditional Chinese medicine and traditional medical techniques,other therapies(lifestyle interven-tions and music therapy)].
国家科技期刊平台
NSTL
万方数据
