首页|14例阑尾子宫内膜异位症临床病理特征分析

14例阑尾子宫内膜异位症临床病理特征分析

Clinical and pathological characteristics analysis of 14 cases of appendiceal endometriosis

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目的:分析阑尾子宫内膜异位症的临床病理特点.方法:回顾分析2005 年8 月至2022 年4 月病理确诊的14 例阑尾子宫内膜异位症患者的临床资料.结果:患者发现阑尾子宫内膜异位症时中位年龄 43.5(35.0,46.0)岁,小于 30 岁占7.1%(1 例),30~40 岁占28.6%(4 例),40~50 岁占50.0%(7 例),大于50 岁占14.3%(2 例).9 例(64.3%)患者术前存在痛经症状,术后痛经症状均缓解.12 例(85.7%)患者病理证实阑尾存在急慢性炎症,4 例(28.6%)临床诊断为原发性不孕症.患者术前检查均未提示阑尾子宫内膜异位症,均为术后病理诊断.1 例(7.1%)患者术前主要诊断为阑尾肿物,1 例(7.1%)主要诊断为卵巢肿物,术前主要诊断为卵巢囊肿、急慢性阑尾炎、卵巢恶性肿瘤、子宫肌瘤各 3 例(21.4%).4 例(28.6%)因阑尾急慢性炎症或阑尾肿物切除阑尾,6 例(42.9%)因术中见阑尾形态异常而切除阑尾,3 例(21.4%)因卵巢恶性肿瘤常规切除阑尾,1 例(7.1%)为右侧附件切除术中见阑尾与卵巢粘连紧密而切除阑尾.3 例合并剥除卵巢囊肿、1 例合并切除右侧卵巢,病理证实均存在卵巢子宫内膜异位囊肿;4 例同时切除子宫及一侧或双侧附件,其中3 例同时存在卵巢子宫内膜异位囊肿及子宫腺肌病,1 例存在子宫腺肌病.阑尾子宫内膜异位位置:肌层7 例(50%),外膜3 例(21.4%),浆膜1 例(7.1%),3 例(21.4%)位于肌层及外膜;1 例合并阑尾黏液腺瘤,1 例合并阑尾黏液腺瘤及阑尾类癌.患者均经腹腔镜手术切除阑尾.结论:对于临床确诊子宫内膜异位症的孕龄期妇女,尤其存在反复右下腹疼痛的患者,妇科与外科医师需仔细鉴别排查阑尾子宫内膜异位症的可能.如果阑尾存在子宫内膜异位,会引起阑尾急、慢性炎症,通常需要手术治疗,需引起妇科及外科医师的高度重视.
Objective:To analyze the clinical and pathological characteristics of appendiceal endometriosis.Methods:A retro-spective analysis was conducted on clinical data of 14 patients with pathologically confirmed appendiceal endometriosis diagnosed from Aug.2005 to Apr.2022.Results:The median age of patients diagnosed with appendiceal endometriosis was 43.5(35.0,46.0)years,with 7.1%(1 case)below the age of 30,28.6%(4 cases)aged 30-40,50.0%(7 cases)aged 40-50,and 14.3%(2 cases)above the ageof50.Amongthe patients,64.3%(9 cases)experienced dysmenorrhea before surgery,and their dysmenorrhea symptoms were relieved after surgery.Pathological examination confirmed the presence of acute or chronic inflammation in 85.7%(12 cases)of the patients.Clinical diagnoses of primary infertility were made in 28.6%(4 cases)of the patients.Preoperative examinations did not suggest appendiceal endometriosis in any of the patients,and the diagnosis was made based on postoperative pathology.The main preop-erative diagnoses were appendiceal masses in7.1%(1 case)of the patients,ovarian masses in 7.1%(1 case),ovarian cysts,acute or chronic appendicitis,ovarian malignancies,and uterine fibroids in 21.4%(3 cases)respectively.As for the source of appendiceal speci-mens,28.6%(4 cases)had the appendix removed due to appendiceal inflammation or appendiceal masses,42.9%(6 cases)had the appendix removed due to abnormal morphology observed during surgery,21.4%(3 cases)had the appendix removed routinely during the resection of ovarian malignancies,and 7.1%(1 case)had the appendix removed due to close adhesion to the right ovary during right adnexectomy.Three cases involved the removal of ovarian cysts,and one case involved the removal of the right ovary;all pathologically confirmed the presence of ovarian endometriotic cysts.Four cases underwent concurrent hysterectomy with unilateral or bilateral adne-xectomy,among which three cases had both ovarian endometriotic cysts and adenomyosis,and one case had adenomyosis alone.The locations of appendiceal endometriosis were 50%(7 cases)in the muscular layer,21.4%(3 cases)in the outer membrane,7.1%(1 case)in the serosa,and21.4%(3 cases)in both the muscular layer and outer membrane.Case1 had concurrent appendiceal mucinous adenoma,and case 13 had concurrent appendiceal mucinous adenoma and appendiceal carcinoid.All patients underwent minimally inva-sive laparoscopic surgery to remove the appendix.Conclusions:For childbearing age women clinically diagnosed with endometriosis,especially those who experience recurrent lower right abdominal pain,gynecologists and surgeons need to carefully consider the possibility of appendiceal endometriosis.If appendiceal endometriosis is present,it is highly likely to cause acute or chronic inflammation in the appendix,which often requires surgical treatment,and gynecologists and surgeons should pay high attention.

Appendiceal endometriosisEndometriosisAppendicitisLaparoscopy

丰硕、陈晓、窦伟冬、郑航、张继新、史阳阳、胡君、贾芃、张峻岭、汪欣

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北京大学第一医院胃肠外科,北京,100034

北京大学第一医院病理科

北京大学第一医院妇产科

阑尾子宫内膜异位症 腹腔镜检查

国家自然科学基金面上项目国家自然科学基金国家重大疾病多学科合作诊疗能力建设项目北京大学第一医院青年临床研究专项北京大学医学部青年培育基金

82372860816410982021CR03BMU2020PYB026

2024

腹腔镜外科杂志
山东大学

腹腔镜外科杂志

CSTPCD
影响因子:0.861
ISSN:1009-6612
年,卷(期):2024.29(2)
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