Comparison of the perioperative and long-term survival effects of laparoscopy and open surgery in the treatment of stage T3-T4a colon cancer:a retrospective study of single center
Objective:To compare the perioperative efficacy and long-term survival of laparoscopic and open surgery for the treatment of stage T3-T4a colon cancer.Methods:Patients with stage T3-T4a colon cancer who underwent laparoscopic and open surgery from Jan.1,2018 to Dec.31,2019 were divided into laparoscopic group(n=102)and open group(n=43).The perioperative data,postoperative complications,overall survival,tumor-free survival time,1-year and 3-year survival rates and tumor-free survival rates,overall survival rates and overall tumor-free survival rates,tumor recurrence and metastasis were analyzed in the two groups.Results:There was no significant difference in baseline data between the two groups(P>0.05).The amount of intraoperative blood loss in the laparoscopic group was less than that in the open group[50.00(20.00,50.00)mL vs.50.00(50.00,100.00)mL,P<0.001].The number of obtained lymph nodes in the laparoscopic group was more than that in the open group[17.00(14.00,22.00)vs.14.00(11.00,20.00),P=0.018].The postoperative recovery time of eating[3.00(3.00,4.00)d vs.4.00(3.00,6.00)d,P<0.001)and exhaust time[3.00(3.00,3.00)d vs.4.00(3.00,5.00)d,P<0.001]in the laparoscopic group was shorter than that in the open group.The incidence of overall postoperative complications and postoperative incomplete intestinal obstruction in laparoscopic group was lower than that in open group(32.35%vs.51.16%,3.92%vs.16.28%,P<0.05).There was no significant difference in 1-year and 3-year survival rate and tumor-free survival rate,overall survival rate,overall tumor-free survival rate,tumor recurrence and metasta-sis between the two groups(P>0.05).In T4a subgroup,there was no significant difference in survival between the two groups(P>0.05).Conclusions:Laparoscopic surgery for T3-T4a stage colon cancer is safe and feasible,and is more conducive to postoperative re-covery.It can achieve the same tumor treatment effects as open surgery.
Colonic neoplasmsRadical resection of colon cancerLaparoscopyLaparotomyComparative effectiveness research
国家科技期刊平台
NSTL
万方数据
