腹腔镜外科杂志2024,Vol.29Issue(6) :406-410.DOI:10.13499/j.cnki.fqjwkzz.2024.06.406

布地奈德联合沙丁胺醇雾化吸入对胸腔镜肺叶切除术患者的治疗效果

Efficacy of budesonide combined with salbutamol nebulized inhalation on thoracoscopic lobectomy patients

胡慧 陈龙 祁聪聪
腹腔镜外科杂志2024,Vol.29Issue(6) :406-410.DOI:10.13499/j.cnki.fqjwkzz.2024.06.406

布地奈德联合沙丁胺醇雾化吸入对胸腔镜肺叶切除术患者的治疗效果

Efficacy of budesonide combined with salbutamol nebulized inhalation on thoracoscopic lobectomy patients

胡慧 1陈龙 2祁聪聪3
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作者信息

  • 1. 济宁市第一人民医院心内科,山东 济宁,272011
  • 2. 山东省戴庄医院药剂科
  • 3. 济宁市第一人民医院呼吸与危重医学科
  • 折叠

摘要

目的:评估布地奈德联合沙丁胺醇雾化吸入对胸腔镜肺叶切除术患者的治疗价值.方法:采用回顾性对照研究的方法,选择2023 年1 月至2024 年1 月行胸腔镜肺叶切除术的172 例患者,根据有无雾化吸入沙丁胺醇将患者分为对照组(n=87)与实验组(n=85),对照组予以布地奈德,实验组予以布地奈德联合沙丁胺醇,两组均于术前1d、术后连续3d进行雾化吸入.监测指标包括术前及术后第3 天的动脉血气分析、C反应蛋白、白细胞计数等炎症标志物、肺部影像学检查.结果:两组患者年龄、性别等差异无统计学意义(P>0.05),术前两组患者PaO2、PaCO2、C反应蛋白、白细胞计数差异无统计学意义(P>0.05),术后实验组PaO2 高于对照组,PaCO2 低于对照组,差异有统计学意义(P<0.05),C反应蛋白水平、白细胞计数均低于对照组,差异有统计学意义(P<0.05),实验组肺炎发生率低于对照组,差异有统计学意义(P<0.05).结论:术前及术后连续雾化吸入布地奈德联合沙丁胺醇可有效改善胸腔镜肺叶切除术后肺功能,减少炎症反应,降低肺部并发症发生风险.

Abstract

Objective:To assess the clinical value of budesonide combined with salbutamol nebulized inhalation in patients who underwent thoracoscopic lobectomy.Methods:This retrospective control study included 172 patients who underwent thoracoscopic lobectomy from Jan.2023 to Jan.2024,and these patients were divided into control group(n=87)and experimental group(n=82)according to the presence or absence of salbutamol inhalation,the control group received budesonide and the experimental group received budesonide combined with salbutamol.The two groups received aerosol inhalation on the day before surgery and consecutive 3 d after surgery.Monitoring indicators included arterial blood gas analysis before surgery and at 3rd day after surgery,blood inflammatory markers(C-reactive protein,WBC count),and lung imaging.Results:There was no significant difference in general conditions inclu-ding age and gender between the two groups(P>0.05).The PaO2,PaCO2,C-reactive protein and WBC were not different between the two groups before operation,the PaO2 in the experimental group was significantly higher than that in the control group.After operation in the experimental group,the PaCO2,C-reactive protein levels,WBC count,and incidence of pneumonia were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Budesonide combinedwithsalbuta-mol aerosol inhalation can effectively improve the pulmonary function,reduce the inflammatory response and risk of lung complications in patients after thoracoscopic lobectomy.

关键词

肺叶切除术/胸腔镜检查/手术后并发症/雾化吸入/布地奈德/沙丁胺醇

Key words

Pulmonary lobectomy/Thoracoscopy/Postoperative complications/Aerosol inhalation/Budesonide/Albuterol

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基金项目

山东省医务职工科技创新计划联合立项项目(SDYWZGKCJHLH2023068)

出版年

2024
腹腔镜外科杂志
山东大学

腹腔镜外科杂志

CSTPCD
影响因子:0.861
ISSN:1009-6612
参考文献量1
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