Objective:To investigate the clinical effect of self-pulling latter transection functional end-to-end esophago-jejunos-tomy(SPLT-FETE)in totally laparoscopic total gastrectomy(TLTG).Methods:Eighteen patients who underwent SPLT-FETE TLTG from Mar.2023 to Feb.2024(observation group)were selected,and 20 patients who underwent laparoscopic total gastrectomy(circular anastomosis)performed by the same surgical team from Dec.2021 to Feb.2023 were selected as the control group.The intraoperative and postoperative conditions and the rates of surgery-related complications in the two groups were compared and analyzed.Results:The surgeries were successfully completed with negative incisal margins and no perioperative deaths.The operation time of the observation group was shorter than that of the control group[(225.89±26.19)min vs.(244.65±22.05)min,P=0.022],and the length of the auxiliary incision was shorter than that of the control group[(6.06±1.00)cm vs.(10.20±1.06)cm,P<0.001],and the differences were statistically significant.No significant difference was found in intraoperative blood loss,the number of lymph node dissected,the first postoperative venting time,postoperative hospital stay and the incidence of surgery-related complication between the two groups(P>0.05).Conclusions:The application of SPLT-FETE in TLTG is safe,feasible and easy to master,which is worthy of clinical promotion.