Objective:To observe the effect of B-ultrasound guided thoracic paravertebral nerve block(TPVB)combined with general anesthesia in elderly patients undergoing thoracoscopic surgery.Methods:From Mar.2021 to Mar.2023,92 elderly patients who underwent thoracoscopic surgery were collected and separated into two groups according to the random number table.The control group(n=46)was given general anesthesia,and the study group(n=46)was given B-ultrasound guided TPVB combined with general anes-thesia.Analgesic effect,recovery quality,stress response indicators,and incidence of postoperative untoward reactions were compared between the two groups.Results:At 6 h,12 h,24 h after surgery,the study group had lower pain visual analogue scores at rest and dur-ing coughing compared to the control group(P<0.05).The spontaneous breathing recovery time,awakening time,extubation time,time of first ambulation,and sedation-agitation score of the study group were all shorter(or lower)than those of the control group(P<0.05).At 2 h after operation,the levels of adrenocortical hormone,norepinephrine,8-iso prostaglandin F2α,and angiotensinⅡin both groups were higher than those before operation(P<0.05),and those in the study group were lower than those in the control group(P<0.05).The total incidence of postoperative untoward reactions in the study group was lower than that in the control group(P<0.05).Conclusions:B-ultrasound guided TPVB combined with general anesthesia has a definite analgesic effect on elderly patients undergoing thoracoscopic surgery,which can improve the recovery quality,reduce stress reaction and postoperative untoward reactions.