Professor GAO Ming-li's Medication Patterns in the Treatment of Acute Gouty Arthritis
Objective:To apply the data mining method to analyze Professor GAO Ming-li's medication principles and patterns in the diagnosis and treatment of acute gouty arthritis,and provide scientific basis for clinical medication.Methods:Collect case data and initial diagnosis prescriptions of 206 patients with acute gouty arthritis treated by professor Gao Ming-li at the Rheumatology Department of Liaoning University of Traditional Chinese Medicine Affiliated Hospital from January 15,2017 to December 15,2021.Gender,age,the four qi and five flavors,channel entry,medicine efficacy,and medicine frequency were analyzed.Software IBM SPSS Modeler 18.0 and SPSS 26.0 were used to perform complex network analysis,association rule analysis,and cluster analysis on the data.Results:Two hundred and six cases were sorted out,with a male to female ratio of 40:1,involving 135 medicines.The most frequent medicines were Bixie(Rhizoma Dioscoreae Hypoglaucae),Zexie(Rhizoma Alismatis),Zhimu(Rhizoma Anemarrhenae),and Yiyiren(Semen Coicis).The four qi were mostly cold,neutral,and warm;the five flavors were mostly bitter,sweet,and acrid,and the channel entry were mainly the kidney,stomach,and liver channels.From the perspective of medicine categories,the majority of them were used for clearing heat,promoting urination and percolating dampness,and dispelling wind and dampness.Association rule analysis identified commonly used medicine pairs and groups,and high-frequency drug clustering analysis aggregates 5 major categories.Conclusion:Professor GAO Ming-li's treatment of acute gouty arthritis is based on medicines of clearing heat,promoting urination and percolating dampness,and dispelling wind and dampness,among which he puts emphasis on medicines of clearing heat,promoting urination and percolating dampness to clear heat and drain dampness,unblock the collaterals and relieve pain,and focuses on medicines with natures of bitter and cold to clear heat and drain dampness and intervene from the kidney channel.He also uses medicines of invigorating the spleen,promoting blood circulation,guiding channels,supplementing and boosting,releasing exterior,dispersing nodules,and relieving pain.