A Study on the Medication Rules of TCM Treating Primary Sj?gren's Syndrome with the Combination of Dryness and Dampness Based on Data Mining
Objective:To summarize the medication rules of the research team in the Rheumatology Department of Dongfang Hospital,Beijing University of Chinese Medicine in the treatment of primary Sjögren's syndrome with the combination of dryness and dampness.Methods:The medical records of patients with primary Sjögren's syndrome with the combination of dryness and dampness from January 2018 to December 2022 were screened.A database was established using software Excel and statistics were conducted.Software Modeler 18.0 was used for analysis of association rules and complex network,and the results were visualized using software Cytoscape.Cluster analysis was conducted using the software SPSS 20.0.Results:A total of 139 prescriptions were included,involving 188 Chinese medicines.A total of 34 Chinese medicines were used with a frequency equal or more than 25 times.Seventy-three drug association combinations were screened out,and complex network analysis resulted in the core Chinese medicine combination:Danshen(Radix et Rhizoma Salviae Miltiorrhizae)-Qinghao(Herba Artemisiae Annuae)-Shihu(Caulis Dendrobii)-Baishao(Radix Paeoniae Alba),and 8 cluster combinations.Conclusion:The clinical medication for primary Sjögren's syndrome with the combination of dryness and dampness is based on the methods of clearing dampness and heat,removing blood stasis and generating fluids,modifying according to the different degrees of"dampness""heat""dryness"and"blood stasis",which provides ideas and references in clinic.
primary Sjögren's synd-romedata miningmedication rulesassocia-tion analysistraditional Chinese medicine
NETL
NSTL
万方数据
