Analysis of the Diagnostic Efficacy of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Reactive Arthritis
Objective:To explore the diagnostic efficacy of neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)in reactive arthritis(ReA)and their relationship with disease treatment.Methods:Seventy-nine ReA patients diagno-sed by the Rheumatology and Immunology Department of Shanxi Bethune Hospital from January 2018 to December 2021 were selected as the ReA group,and 92 healthy examinees were selected as the healthy control group.The NLR,PLR,blood routine,C-reac-tive protein(CRP),and erythrocyte sedimentation rate(ESR)between the ReA group and the healthy control group were compared.Spearman correlation analysis was used to analyze the correlation between NLR,PLR,blood routine,CRP,and ESR in ReA patients.NLR,PLR,and their diagnostic value in ReA patients were evaluated by drawing receiver operating characteristic(ROC).Finally,the changes in monocyte count,lymphocyte count,CRP,ESR,NLR,and PLR before and after treatment were compared.Results:The NLR and PLR of the ReA group were higher than those of the healthy control group,and the NLR and PLR of ReA patients infected for less than two weeks were higher than those infected for those infected for two or more than two weeks(P<0.05).In the ReA group,NLR and PLR were positively correlated with white blood cell count,neutrophil count,monocyte count,CRP and ESR,PLR was positively correlated with platelet count,and NLR and PLR were negatively correlated with lymphocyte count(P<0.05).According to the ROC,the optimal cutoff value for NLR diagnosis of ReA is 3.41(sensitivity is 57.00%,specificity is 96.70%,AUC=0.81),the optimal cutoff value for PLR diagnosis of ReA is 140.58(sensitivity is 77.20%,specificity is 77.20%,AUC=0.85),and the sensitivity for combined diagnosis of NLR and PLR is 78.80%,specificity is 91.00%,and AUC=0.85;the optimal cutoff value for CRP diagnosis of ReA is 8.16(sensitivity is 78.50%,specificity is 100.00%,AUC=0.89),and the optimal cutoff value for ESR diagnosis of ReA is 19.50(sensitivity is 84.80%,specificity is 96.70%,AUC=0.91).The efficacy of combined diagnosis of NLR and PLR is higher than the single detection by each,but slightly lower than that of CRP and ESR(Z=4,Z=3.58,P<0.05).Further comparison of ReA patients before and after treatment showed a significant decrease in NLR and PLR(P<0.05).Conclusion:NLR and PLR can be used to assist in the diagnosis of ReA and have certain guiding significance for the patient's infection history.Both have a certain clinical value in reflecting the therapeutic effect.
万方数据
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