A Survey and Study on Biomolecular Targeted Therapy for Elderly Rheumatoid Arthritis in Beijing Hospital
Objective:To investigate the use of biologically targeted agents,as well as the use and non use of biologically targeted agents in combination with steroids in elderly patients with rheumatoid arthritis(RA)who have visited Beijing Hospital in the past three years,to study the degree of disease remission,medication adherence,and medication discontinuation.Methods:One hundred and eighty elderly RA patients who visited Beijing Hospital from June 2019 to June 2022 were selected as the research subjects.The hospital's electronic medical record system was used to extract medical information of elderly RA patients,including gender,age,disease course,laboratory tests,drug use,and reasons for discontinuation.Software SPSS 25.0 was used for statistical analysis.Results:①Among the elderly patients with RA,51 patients were selected to use biomolecular targeted therapy.The drug selection in descending order of proportion was tumor necrosis factor antagonist,Janus kinase inhibitor,and interleukin-6 receptor antagonist.② Twenty-five cases of patients using targeted biological agents were tracked regularly.The number of swollen and tender joints,C-reactive protein test results,etc.were counted at the initial diagnosis,three and six months of medication,and the degree of disease activity was determined based on the SDAI scoring formula.Regular use of biological agents for treatment for half a year resulted in disease remission.③Tracking and analyzing the reasons for discontinuation of medication in 26 patients who did not follow the prescribed medication regimen showed that infections and tumors were more common.④Among the 180 patients,the hormone use rate in patients treated with regular biomolecular targeted therapy was significantly reduced compared to patients treated with traditional anti rheumatic drugs to improve their condition.Conclusion:Currently,for elderly patients with RA seeking medical treatment in Beijing Hospital,the main drug selection for biological agents or molecular targeted therapies is tumor necrosis factor receptor antagonists.Regular use of biological agents or molecular targeted drugs can effectively control diseases,alleviate joint swelling and pain symptoms,and reduce disease activity.During the treatment of elderly RA,attention should be paid to monitoring the risk of infection and tumor,and patient follow-up should be carried out.Cooperation with patient families should be actively enhanced to promote regular medication use and reduce drug discontinuation caused by poor compliance.
rheumatoid arthritisthe elderlybiological agentsmolecular targeted drugsdisease activitydiscontinuation factorssurvey and study
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