首页|基于数据挖掘《中华医典》治疗类风湿关节炎用药规律研究

基于数据挖掘《中华医典》治疗类风湿关节炎用药规律研究

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目的:通过搜集医案,分析治疗类风湿关节炎的用药规律.方法:将《中华医典》收集的医案方剂导入古今医案云平台(V2.3.7),借助其数据挖掘功能分析药物使用频次,四气五味、归经、功效分布,药物的关联、聚类、社团、复杂网络分析.结果:收集到符合条件的处方 175 个,共计 239 种药物,使用频次 2025 次,药物频次≥30 次的药味有 18 个,排名前 6 位的高频药物依次为当归、桂枝、牛膝、秦艽、茯苓、桑枝.四气分布以温、平为主,五味以甘、辛、苦为主,归经以肝、脾、肺经为主.药物功效主要集中于祛风湿、祛风除湿.排名前3位关联药物组合为牛膝-当归、秦艽-当归、桑枝-当归.对频次前 25 位的药味进行聚类分析,得到 3 个核心药物组合.进一步对 239 种中药进行分析,得到 4 个核心组团,配伍规律 50 条.结论:治疗类风湿关节炎的中药以祛风湿、祛风除湿、补肝肾、强筋骨为主,兼顾利水、止痛、补血活血、清热等,标本同治.
Research on the Medication Rules for Treating Rheumatoid Arthritis Based on Data Mining from The Chinese Medical Dictionary
Objective:To analyze the medication rules for treating rheumatoid arthritis by collecting medical records.Methods:The prescriptions of medical cases collected from The Chinese Medical Dictionary were imported into the Ancient and Modern Medical Case Cloud Platform(V2.3.7),and its data mining function was used to analyze the frequency of drug use,the four qi and five flavors,meridian tropism,efficacy distribution,drug as sociation,clustering,community,and complex network analysis.Results:A total of 175 eligible prescriptions were collected,with a total of 239 types of drugs used 2025 times.There were 18 medicinal flavors with a frequency of more than 30 times.The top 6 high-frequency drugs were Danggui(Radix Angelicae Sinensis),Guizhi(Ramulus Cinnamomi),Niuxi(Radix Achyranthis Bidentatae),Qinjiao(Radix Gentianae Macrophyllae),Fuling(Poria)and Sangzhi(Ramulus Mori).The distribution of the four qi is mainly warm and calm,the five flavors are mainly sweet,spicy,and bitter,and the meridian is mainly composed of the liver,spleen,and lung meridians.The main efficacy of drugs is focused on dispelling wind and dampness.The top three core drug combinations are Niuxi and Danggui,Qinjiao and Danggui,Sangzhi and Danggui.Cluster analysis was conducted on the top 25 medicinal flavors in terms of frequency,resulting in three core drug combinations.Further analysis was conducted on 239 traditional Chinese medicines,resulting in 4 core groups and 50 compatibility rules.Conclusion:Traditional Chinese medicine for treating rheumatoid arthritis mainly focuses on dispelling wind and dampness,tonifying liver and kidney,and strengthening muscles and bones,also taking into account diuresis,pain relief,blood supplementation and circulation,and heat clearing,achieving the same treatment for both symptoms and root causes.

rheumatoid arthritisThe Chinese Medical DictionaryAncient and Modern Medical Case Cloud Platformmedication rulesdata mining

蔡国昌、安阳、杨佳霞、赵青青、文红、谢良山

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贵州中医药大学,贵州 贵阳 550025

贵州中医药大学第二附属医院,贵州 贵阳 550002

类风湿关节炎 《中华医典》 古今医案云平台 用药规律 数据挖掘

贵州省中医风湿免疫病临床研究中心项目贵州省高等学校中西医结合防治疾病转化医学重点实验室贵州中医药大学国家与省级科技创新人才团队培育项目

黔科合平台人才[2020]2202号黔教技[2023]017号贵中医TD合字[2022]004号

2024

风湿病与关节炎
中华中医药学会

风湿病与关节炎

影响因子:1.216
ISSN:2095-4174
年,卷(期):2024.13(9)