Study on the Expression Levels and Correlation of Chemokines in Late-stage Knee Osteoarthritis of Native Tibetan Patients
Objective:To detect the levels of chemokines in serum and joint fluid of late-stage knee osteoarthritis in Tibetan patients and explore their clinical significance.Methods:Twenty patients with knee osteoarthritis who had underwent total knee replacement surgery from May 2023 to August 2023 were randomly selected.Luminex multi factor detection technology was used to detect the expression levels of 34 cytokines in the serum and joint fluid.VAS and WOMAC were used to evaluate the degree of joint pain and functional impairment.The correlation between 34 cytokines and VAS score,WOMAC score,hemoglobin,CRP,and ESR were analyzed.Results:There was no statistically significant difference in the concentration levels of SDF-1α,IP-10,MIP-1β,and MCP-1 among the 34 cytokines in the serum and joint fluid(P>0.05);there was a positive correlation(P<0.05)between SDF-1α,IP-10,Eotaxin,and MIP-1β in the joint fluid group and the serum group;the levels of SDF-1α and MCP-1 in joint fluid were positively correlated with WOMAC score(P<0.05),and IP-10 was positively correlated with CRP and ESR(P<0.05);the level of Eotaxin in joint fluid is negatively correlated with BMI;the levels of 34 cytokines detected were not significantly correlated with VAS score and WOMAC score.Conclusion:Chemokines are produced in the joint fluid and peripheral blood of late-stage knee osteoarthritis in Tibetan patients,which may provide reference for the diagnosis and treatment of early knee osteoarthritis.
万方数据
维普
