细胞衰老在放射损伤发生发展中的研究进展
Research progress of cell senescence in the occurrence and development of radiation injury
牛晓凤 1杨思瑜 1邓丽娟 1任钲 1毕承柳 1杨军1
作者信息
- 1. 昆明医科大学第三附属医院 云南省肿瘤医院,昆明 650118
- 折叠
摘要
放射损伤是肿瘤患者放射治疗的常见并发症,其发生率高,防治困难,严重影响患者的生活质量.细胞衰老是一种细胞周期停滞的状态,放射治疗通常会促使受照射细胞进入衰老状态,这有利于体内肿瘤细胞的清除,同时也对正常细胞产生伤害.随着研究的不断深入,电离辐射诱导的细胞衰老在放射损伤中发挥的作用越来越受到重视,本文对细胞衰老在放射损伤中的研究进展进行综述.
Abstract
Radiation injury is a common complication of radiotherapy for cancer patients.Radiation injury has a relative high incidence and is difficult to prevent and to be treated,which may seriously affects the life quali-ty of patients.Cell senescence is a state in which the cell cycle is stagnated,and radiation therapy usually makes cells enter a state of senescence,which facilitates the removal of tumor cells in the body while may also causing damage to normal cells.With the progress of research,the role of ionizing radiation-induced cell se-nescence in radiation injury has received more and more attention,and the research progress of cell senes-cence in radiation injury is reviewed in this paper.
关键词
细胞衰老/电离辐射/放射损伤Key words
cell senescence/ionizing radiation/radiation injury引用本文复制引用
出版年
2024
NETL
NSTL
万方数据