首页|Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

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The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient satisfaction.However,there is renewed opti-mism for addressing these challenges through the innovative realm of Four-Dimensional(4D)printing.This groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external stimuli.Consequently,implants crafted using 4D printing offer significant potential for dynamic adjustments.Inspired by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation prosthesis.The choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human body.This attribute allowed for temperature-responsive intraopera-tive self-deformation and postoperative remodeling.Our chosen animal model for experimentation was rabbits.Taking into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior biocompatibility.These prostheses were then surgically implanted in a minimally invasive manner into the rabbit noses.Remarkably,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days post-surgery.Subsequent histological evaluations confirmed the practical viability of these prostheses in a living organism.Our research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

4D printingShape memory polyurethaneRhinoplastySelf-deformationDynamic aesthetic adjustment

Jiaqi Liu、Guiwei Li、He Liu、Jincheng Wang、Hui Wang、Xue Gao、Qingping Liu、Chenyu Wang

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Department of Plastic and Reconstructive Surgery,The First Hospital of Jilin University,Changchun 130021,China

Department of Orthopaedics,The Second Hospital of Jilin University,Changchun 130041,China

Key Laboratory of Bionic Engineering(Ministry of Education),Jilin University,Changchun 130022,China

talent reserve program of the first hospital of Jilin UniversityNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScientific Development Program of Jilin ProvinceScientific Development Program of Jilin ProvinceScientific Development Program of Jilin ProvinceScientific Development Program of Jilin ProvinceScientific Development Program of Jilin ProvinceProgram of Jilin Provincial Health DepartmentProgram of Jilin Provincial Health DepartmentProject of"Medical+X"Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin UniversityChina Postdoctoral Science FoundationBethune Plan of Jilin UniversityBethune Plan of Jilin University

JDYY-TRP-20240028237239182001971821023588220269820200403088SF20220204117YYYDZJ202201ZYTS08620200404202YY20200802008GH2020SC2T0642020SC2T0652022JBGS062021M7013842022B272022B03

2024

10.1007/s42235-024-00503-9

仿生工程学报(英文版)
吉林大学

仿生工程学报(英文版)

CSTPCDEI
影响因子：0.837
ISSN：1672-6529
年,卷(期)：2024.21(3)
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