首页|Bioinspired Hollow Mesoporous Silica Nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

Bioinspired Hollow Mesoporous Silica Nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

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3D-printed Porous Titanium Alloy Implants(pTi),owing to their biologically inertness and relatively smooth surface morphology,adversely affect the biological functions of surrounding cells.To address the challenges,constructing a bio-inspired interface that mimics the hierarchical structure of bone tissue can enhance the cellular functions of cells.In this context,Hollow Mesoporous Silica Nanoparticles(HMSNs),renowned for their unique physicochemical properties and superior biocompatibility,offer a promising direction for this research.In this research,the initially synthesized HMSNs were used to construct a"hollow-mesoporous-macroporous"hierarchical bioinspired coating on the pTi surface through the Layer-by-Layer technique.Simultaneously,diverse morphologies of coatings were established by adjusting the depo-sition strategy of PDDA/HMSNs on the pTi surface(pTi-HMSN-2,pTi-HMSN-4,pTi-HMSN-6).A range of techniques were employed to investigate the physicochemical properties and regulation of cellular biological functions of the diverse HMSN coating strategies.Notably,the pTi-HMSN-4 and pTi-HMSN-6 groups exhibited the uniform coatings,leading to a substantial enhancement in surface roughness and hydrophilicity.Meantime,the coating constructed strategy of pTi-HMSN-4 possessed commendable stability.Based on the aforementioned findings,both pTi-HMSN-4 and pTi-HMSN-6 facilitated the adhesion,spreading,and pseudopodia extension of BMSCs,which led to a notable upsurge in the expres-sion levels of vinculin protein in BMSCs.Comprehensive analysis indicates that the coating,when PDDA/HMSNs are deposited four times,possesses favorable overall performance.The research will provide a solid theoretical basis for the translation of HMSN bioinspired coatings for orthopedic implants.

Hollow mesoporous silica nanoparticlesBioinspired coatingTitanium alloyHierarchical structureCellular functions

Jiaxin Zhang、He Liu、Jincheng Wang、Jing Shang、Mingwei Xu、Xiujie Zhu、Chao Xu、Haotian Bai、Xin Zhao

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Orthopedic Institute of Jilin Province,Orthopedic Medical Center,The Second Hospital of Jilin University,Changchun 130041,China

Key Laboratory of Bionic Engineering(Ministry of Education),Jilin University,Changchun 130025,China

Institute of Structured and Architected Materials,Liaoning Academy of Materials,Shenyang 110167,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaProject of"Medical+X"interdisciplinary innovation team of Norman Bethune Health Science Center of Jilin UniversityProject of youth interdisciplinary innovation team of Jilin UniversityChina Postdoctoral Science FoundationBethune Plan of Jilin UniversityBethune Plan of Jilin UniversityWu Jieping Medical FoundationScientific Development Program of Jilin ProvinceJilin Province Development and Reform Commission

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2024

10.1007/s42235-024-00511-9

仿生工程学报(英文版)
吉林大学

仿生工程学报(英文版)

CSTPCDEI
影响因子：0.837
ISSN：1672-6529
年,卷(期)：2024.21(3)
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