首页|Influence of Biomimetic Apatite Coating on the Biobehavior of TiO2 Scaffolds

Influence of Biomimetic Apatite Coating on the Biobehavior of TiO2 Scaffolds

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Immersion of scaffolds in Simulated Body Fluid(10SBF)is a standardized method for evaluating their bioactivity,simu-lating in vivo conditions where apatite deposits can be formed on the surface of scaffold,facilitating bone integration and ensuring their suitability for bone implant purposes,ultimately contributing to long-term implant success.The effect of apatite deposition on bioactivity and cell behavior of TiO2 scaffolds was studied.Scaffolds were soaked in 10SBF for different durations to form HAP layer on their surface.The results proved the development of a hydroxyapatite film resembling the mineral composition of bone Extracellular Matrix(ECM)on the TiO2 scaffolds.The XRD test findings showed the presence of hydroxyapatite layer similar to bone at the depth of 10 nm.A decrease in the specific surface area(18.913 m2g-1),the total pore volume(0.045172 cm3g-1(at p/p0=0.990)),and the mean pore diameter(9.5537 nm),were observed by BET analysis which confirmed the formation of the apatite layer.It was found that titania scaffolds with HAP coating promoted human osteosarcoma bone cell(MG63)cell attachment and growth.It seems that immersing the scaffolds in 10SBF to form HAP coating before utilizing them for bone tissue engineering applications might be a good strategy to promote bioactivity,cell attachment,and implant fixation.

TitaniaHierarchical meso/macro porous10SBFBiomimetic apatiteCoating

Shima Mahtabian、Seyed Mehdi Mirhadi、Nahid Hassanzadeh Nemati、Melika Sharifi、Fariborz Tavangarian

展开 >

Department of Biomedical Engineering,University of Delaware,Newark,DE 19716,USA

Department of Ceramic Engineering,Islamic Azad University(Shahreza Branch),Shahreza,Isfahan 86145-311,Iran

Department of Biomedical Engineering,Islamic Azad University(Science and Research Branch),Tehran,Iran

Department of Materials Science & Engineering,Islamic Azad University(Najaf Abad Branch),Najaf Abad,Isfahan 8514143131,Iran

Mechanical Engineering Program,School of Science,Engineering and Technology,Pennsylvania State University,Harrisburg,Middletown,PA 17057,USA

Biomedical Engineering Department,Pennsylvania State University,State College,University Park,Pennsylvania 16802,USA

展开 >

2024

10.1007/s42235-024-00547-x

仿生工程学报(英文版)
吉林大学

仿生工程学报(英文版)

CSTPCDEI
影响因子：0.837
ISSN：1672-6529
年,卷(期)：2024.21(4)