首页|Research on the Influencing Factors of Peristalsis Amplitude Based on an in Vitro Bionic Rat Stomach Model

Research on the Influencing Factors of Peristalsis Amplitude Based on an in Vitro Bionic Rat Stomach Model

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The In Vitro Bionic Digestion Model(IVBDM)are used to simulate the digestion process of food or pharmaceuticals in corresponding digestion tracts for obtaining the digestion data,which are expected to replace in vivo experiments with ani-mals in the early stages of functional food or drug development,and thus have broad applications prospects.However,little is known so far about how the factors including the Young's modulus of the model,the level,location and direction of the applied load,affect the peristalsis amplitude of the IVBDM.Based on an In Vitro Bionic Rat Stomach Model(IVBRSM),simulation and experimental analysis were conducted to examine the factors effecting the peristalsis amplitude of the IVBRSM.It is shown that Young's modulus of the model significantly affects the peristalsis amplitude,with lower Young's modulus resulting in larger amplitude.Load level,location,and direction also influence the peristalsis amplitude.Addition-ally,IVBRSM size and wall thickness play a role,with larger models requiring higher load levels or lower Young's modulus for the same peristalsis amplitude.Simulation data correlate well with experimental results.These findings contribute to the understanding of the peristalsis state of IVBRSM under different conditions and can guide the design and fabrication of such in vitro bionic digestion models.

BionicIn vitro digestion modelsRat stomachPeristalsis amplitudeYoung's modulus

Wentao Liang、Keyong Zhao、Peng Wu、Changyong Li、Xiaodong Chen、Renpan Deng、Zhigang Lei

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School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering of Xinjiang Bingtuan,Shihezi University,Shihezi 832003,China

School of Chemical and Environmental Engineering,and Key Laboratory of Coal-Based Energy and Chemical Industry,Xinjiang Institute of Engineering,Xinjiang 830091,China

School of Chemical and Environmental Engineering,Soochow University,Suzhou 215123,China

Fujian Provincial Key Laboratory of Biochemical Technology & Institute of Biomaterials and Tissue Engineering,College of Chemical Engineering,Huaqiao University,Xiamen 361021,China

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2024

10.1007/s42235-024-00566-8

仿生工程学报(英文版)
吉林大学

仿生工程学报(英文版)

CSTPCDEI
影响因子：0.837
ISSN：1672-6529
年,卷(期)：2024.21(5)