Effect of Silagilan Tablets Combined with Levodopa Tablets on Serum Related Indicators and Mental State in Patients with Parkinson's Disease
Objective To investigate the effect of Silagilan tablets combined with levodopa tablets on serum related indicators and mental state in patients with Parkinson's disease(PD).Methods 70 PD patients admitted to Gaomi People's Hospital from February 2021 to February 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 35 cases in each group.The control group was treated with levodopa tablets,and the observation group was treated with Selegiline tablets on the basis of the control group.Both groups were treated for 10 weeks.The serum related indexes,clinical efficacy,mental state and cognitive function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.14%,higher than 77.14% of the control group,and the difference was statistically significant(P﹤0.05).After treatment,the levels of brain-derived neurotrophic factor,nerve growth factor and insulin growth factor in the observation group were(5.49±0.55)ng/mL,(148.74±16.05)ng/mL and(118.65±12.74)ng/mL,respectively,the levels were higher than(4.84±0.26)ng/mL,(133.84±15.28)ng/mL and(101.09±10.58)ng/mL of the control group,and the differences between groups were statistically significant(P﹤0.05);the score of the national Scale of psychiatric symptoms in the observation group was(11.47±1.65)points,lower than(19.44±1.46)points in the control group,and the score of the Montreal Cognitive Assessment Scale was(26.94±2.85)points,higher than(24.14±2.23)points in the control group,and the differences between groups were statistically significant(P﹤0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P﹥0.05).Conclusion The combination of Silagilan tablets and levodopa tablets can effectively upregulate the levels of BDNF,NGF,and IGF-1 in PD patients,promote improvement in their mental state,enhance their cognitive function,and is safe and feasible.
Parkinson's diseaseSilaijilan tabletsLevodopa tabletsSerum related indicatorsMental stateCognitive functionAdverse reactions
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