Effect of Transnasal High-Flow Humidification Oxygen Therapy Combined with Bronchoalveolar Lavage on Respiratory Mechanical Indicators and Levels of Inflammatory Factors in Patients with Severe Pneumonia
Objective To analyze the effects of transnasal high-flow humidification oxygen therapy(HFNC)combined with bronchoalveolar lavage(BAL)in patients with severe pneumonia.Methods 60 patients with severe pneumonia admitted to the hospital from January 2022 to September 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group received BAL,and the observation group received HFNC in addition to the control group.Both groups received continuous treatment for 2 weeks.The clinical efficacy,respiratory indexes,blood gas analysis and inflammatory factors were compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was higher than 70.00%of the control group,and the difference was statistically significant(P＜0.05).After 2 weeks of treatment,the airway resistance was(8.14±1.01)[cmH2O/(L·s)]and the PCO2 was(35.69±2.15)mmHg(1 mmHg=0.133 kPa),interleukin-6(101.35±8.34)pg/mL,C-reactive protein(9.53±1.56)mg/L,tumor necrosis factor-α(15.34±2.12)ng/L,they were lower than(10.35±1.57)[cmH2O/(L·s)],(40.21±2.53)mmHg,(113.59±10.58)pg/mL,(13.25±2.01)mg/L,(19.71±2.59)ng/L of the control group,the dynamic lung compliance was(39.84±6.45)mL/cmH2O and the oxygen pressure was(88.95±10.21)mmHg,which were higher than(35.20±5.21)mL/cmH2O and(79.63±8.46)mmHg of the control group,and the differences between groups were statistically significant(P＜0.05).Conclusion HFNC combined with BAL can restore respiratory mechanics,improve blood gas analysis,and reduce inflammatory factor response.
Severe pneumoniaBronchoalveolar lavageRespiratory mechanicsInflammatory factors
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