Effect of Shexiang Baoxin Pill Combined with Isosorbide Mononitrate on the Clinical Efficacy of Patients with Angina Pectoris of Coronary Heart Disease
Objective To explore the application effect of Shexiang Baoxin pill combined with isosorbide mononitrate(ISMI)in patients with angina pectoris of coronary heart disease.Methods 104 patients with angina pectoris of coronary heart disease admitted to our hospital from May 2021 to June 2022 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 52 cases in each group.The control group was treated with ISMI,and the observation group was treated with Shexiang Baoxin pill on the basis of the control group.The therapeutic effect and safety of the two groups were compared.Results The total effective rate of the observation group was 96.15％,which was higher than 82.69％ of the control group,and the difference was statistically significant(P＜0.05).Before treatment,there were no statistically significant differences in angina pectoris attack,cardiac function indexes,and hemorheology indexes between the two groups(P＞0.05);after treatment,the frequency of angina pectoris attack was(2.77±0.58)times/week,less than(3.52±0.65)times/week in the control group,the duration of angina pectoris was(2.39±0.38)min,shorter than(3.10±0.45)min in the control group,and the level of left ventricular ejection fraction was(55.40±5.13)％,higher than(50.31±4.35)％ in the control group,the left ventricular end-diastolic diameter was(49.23±4.19)mm and left ventricular end-systolic diameter was(43.10±4.11)mm,which were shorter than(58.09±5.81)mm,(47.37±4.72)mm in the control group.The whole blood specific high shear viscosity was(5.21±0.72)mpa·s,the whole blood specific low shear viscosity was(8.79±1.34)mpa·s,the plasma specific viscosity was(1.30±0.31)mpa·s,and the whole blood viscosity level was(2.18±0.48)mpa·s,compared with(6.14±0.86)mpa·s,(10.32±1.27)mpa·s,(1.73±0.44)mpa·s,(3.01±0.77)mpa·s of the control group,the differences between the groups were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shexiang Baoxin pills combined with ISMI in the treatment of patients with angina pectoris of coronary heart disease can enhance its clinical efficacy,reduce angina pectoris,improve hemorheological indexes and cardiac function,and has fewer adverse reactions.
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