Effect of Exercise Therapy Combined with Paricalcitol in the Treatment of MHD Patients with Secondary Hyperparathyroidism and Its Influence on FGF23 and Klotho Protein Levels
Objective To investigate the effect of exercise therapy combined with paricalcitol on maintenance hemodialysis(MHD)patients with secondary hyperparathyroidism(SHPT)and its influence on the levels of fibroblast growth factor 23(FGF23)and Klotho protein.Methods 94 patients with MHD combined with SHPT admitted to Jianshi County Third Hospital from February 2022 to February 2023 were selected as the study objects and were divided into a control group(n=47)and an observation group(n=47)according to the random number table method.The control group was treated with paricalcitol,and the observation group was treated with exercise therapy on this basis.The calcium and phosphorus metabolism,serological indexes level and quality of life were compared between the two groups.Results After treatment,the blood phosphorus level in the observation group was lower than that in the control group,and the blood calcium level was higher than that in the control group,the differences between the two groups were statistically significant(P＜0.05).After treatment,the Klotho protein in the observation group was(148.15±4.26)μ/L,which was higher than(143.64±4.26)μ/L in the control group,while the levels of FGF23 and intact parathyroid hormone(iPTH)were(102.64±10.27)ng/L and(254.43±58.61)ng/L,respectively,which were lower than(114.26±11.54)ng/L and(324.54±54.14)ng/L of the control group,the differences between the two groups were statistically significant(P＜0.05).After treatment,the kidney disease-targeted areas score in the observation group was(69.23±9.36)points,which was higher than(61.35±8.26)points in the control group,and the difference was statistically significant(P＜0.05).Conclusion Exercise therapy combined with paricalcitol in MHD patients with SHPT can regulate iPTH,FGF23 and Klotho protein,effectively improve the metabolism of calcium and phosphorus,and improve the quality of life.
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