Effect of Mindfulness-Decompression Therapy Combined with Oxycodone Hydrochloride Extended-Release Tablets in the Treatment of Refractory Cancer Pain and Its Influence on Inflammatory Indicators and Pain Mediators Levels
Objective To investigate the effect of mindfulness-decompression therapy combined with oxycodone hydrochloride extended-release tablets in the treatment of refractory cancer pain.Methods 80 patients with refractory cancer pain admitted to Liaocheng People's Hospital from January 2020 to June 2021 were selected as research objects,and were divided into a control group and an observation group according to random number table method,with 40 cases.The control group was treated with oxycodone hydrochloride extended-release tablets,and the observation group was treated with mindfulness-decompression therapy on the basis of the control group.Both groups were treated for 4 weeks.The clinical efficacy,inflammatory indexes and pain mediators were compared between the two groups.Results The total effective rate of the observation group was 95.00%,which was higher than 77.50%of the control group,the difference was statistically significant(P＜0.05).After treatment,the interleukin-6 and tumor necrosis factor-α in the observation group were(123.06±21.47)ng/L and(154.60±31.70)ng/L,respectively,which were lower than(165.62±24.08)ng/L and(379.65±35.62)ng/L in the control group,the differences between the groups were statistically significant(P＜0.05).After treatment,the substance P and prostaglandin E2 in the observation group were(10.78±0.87)ng/mL and(33.28±5.17)ng/L,respectively,which were lower than(16.33±1.65)ng/mL and(75.79±7.86)ng/L in the control group,while the β-endorphin was(255.46±30.47)ng/L,which was higher than(212.02±29.32)ng/L in the control group,and the differences between the groups were statistically significant(P＜0.05).Conclusion Mindful-Decompression therapy combined with oxycodone hydrochloride extended-release tablets can significantly reduce the pain degree of refractory cancer pain patients,reduce the inflammatory response,improve the pain mediator levels,and obtain better analgesic effect.
Refractory cancer painMindful-Decompression therapyOxycodone hydrochloride extended-release tabletsInflammatory indicatorsPain mediatorsClinical efficacy
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