Effect of Microchannel Percutaneous Nephrolithotomy Combined with Negative Pressure Suction Clear Stone Sheath on Renal Function and Renal Blood Flow in Patients with Complex Renal Calculi
Objective To investigate the clinical effect of micro channel percutaneous nephrolithotomy(PCNL)combined with negative pressure suction clear stone sheath(VMP)in the treatment of complex renal calculi.Methods A total of 76 patients with complex renal calculi admitted to our hospital from June 2021 to June 2023 were selected as the research objects,and were randomly divided into a control group and an observation group,with 38 cases in each group.The control group was treated with micro channel PCNL,and the observation group was treated with VMP on the basis of the control group.The operation conditions,renal function indexes,renal blood flow indexes,stress response,stone clearance rate and complications were compared between the two groups.Results The operation time and hospitalization time in the observation group were(82.63±6.25)min and(6.85±1.15)d,respectively,which were shorter than(98.74±7.89)min and(8.41±1.26)d in the control group,and the intraoperative blood loss was(61.32±5.89)mL,which was less than(80.41±6.87)mL in the control group,and the differences between the two groups were statistically significant(P＜0.05).After operation,the levels of blood urea nitrogen and blood creatinine in the observation group were(8.95±1.17)mmol/L and(87.04±7.34)μmol/L,respectively,which were lower than(11.48±1.26)mmol/L and(97.74±7.89)μmol/L in the control group,the differences between the two groups were statistically significant(P＜0.05).After operation,the peak renal aortic systolic flow rate in the observation group was(67.35±5.89)cm/s,which was faster than(62.41±5.76)cm/s in the control group,and the difference was statistically significant(P＜0.05).After operation,the levels of cortisd,adrenaline and adrenocortical hormones in the observation group were(98.65±8.34)nmol/L,(228.63±20.35)ng/mL and(28.56±2.81)ng/L,respectively,which were lower than(113.29±11.54)nmol/L,(246.73±22.47)ng/mL,(34.63±3.15)ng/L in the control group,the differences were statistically significant between the two group(P＜0.05).There was no significant difference in stone clearance rate between the two groups(P＞0.05);the incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Microchannel PCNL combined with VMP is more effective in the treatment of complex renal calculi,which can shorten the operation time,further reduce the trauma of the body,and protect the renal function and renal blood flow of patients.It is safe and reliable.
Complex renal calculiMicrochannel percutaneous nephrolithotomyNegative pressure suction clear stone sheathRenal function
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