小儿肺咳颗粒和阿奇霉素联合治疗小儿支原体肺炎的效果及对症状消失时间、炎症反应的影响
Effect of Xiaoer Feike Granule and Azithromycin in the Treatment of Mycoplasma Pneumonia in Children and Its Influence on the Time of Symptom Disappearance and Inflammation
王英冰1
作者信息
- 1. 东营港经济开发区中心医院儿科,山东东营 257237
- 折叠
摘要
目的 探究小儿肺咳颗粒和阿奇霉素联用在治疗小儿支原体肺炎中的应用效果.方法 选取 2021 年5 月—2023 年5 月东营港经济开发区中心医院收治的 80 例支原体肺炎患儿为研究对象,按随机数字表法将其分为对照组(n=40)、观察组(n=40),其中对照组采用阿奇霉素治疗,观察组在对照组基础上加用小儿肺咳颗粒治疗,比较两组临床疗效、症状消失时间、炎症反应、肺功能指标及不良反应发生情况.结果 观察组治疗总有效率为 95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05).观察组症状消失时间短于对照组,差异有统计学意义(P<0.05).治疗后,观察组C反应蛋白、肿瘤坏死因子-α及白细胞介素-6 水平均低于对照组,第 1 秒用力呼气容积、最大肺活量水平均大于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论 小儿肺咳颗粒和阿奇霉素联用可加快小儿支原体肺炎临床症状消失,减轻炎症反应,改善肺功能,安全性较高.
Abstract
Objective To explore the effect of Xiaoer Feike Granules combined with azithromycin in the treatment of mycoplasma pneumonia in children.Methods 80 children with mycoplasma pneumonia admitted to the Central Hospital of Dongyinggang Economic Development Zone from May 2021 to May 2023 were selected as the research objects.They were divided into a control group(n=40)and an observation group(n=40)according to the random number table method.The control group was treated with azithromycin,and the observation group was treated with Xiaoar Feike Granules on the absis of the control group.The clinical efficacy,symptom disappearance time,inflammatory response,pulmonary function index and adverse reactions were compared between the two groups.Results The overall response rate of the observation group was 95.00%,which was higher than 77.50%of the control group,and the difference was statistically significant(P<0.05).The symptom disappearance time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of inflammatory response indexes C-reactive protein,tumor necrosis factor-α and interleukin-6 in the observation group were lower than those in the control group,and the levels of forced expiratory volume in the first second and maximum vital capacity were greater than those in the control group,the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiaoer Feike Granule combined with azithromycin can accelerate the disappearance of clinical symptoms of mycoplasma pneumonia in children,reduce inflammatory response,improve lung function,with high safety.
关键词
小儿支原体肺炎/小儿肺咳颗粒/阿奇霉素/临床症状/炎症反应Key words
Mycoplasma pneumonia in children/Xiaoer Feike Granules/Azithromycin/Clinical symptoms/Inflammatory response引用本文复制引用
出版年
2024
NETL
NSTL
万方数据