Clinical Efficacy of Isotretinoin Capsule Intermittent Therapy Combined with Isotretinoin Erythromycin Gel in the Treatment of Moderate to Severe Acne
Objective To investigate the clinical effect of isotretinoin capsule intermittent therapy combined with isotretinoin erythromycin gel in the treatment of moderate and severe acne.Methods 172 patients with moderate to severe acne admitted to our hospital from October 2022 to August 2023 were selected as the research objects,and they were divided into a study group(n=86)and a control group(n=86)according to the random number table method.The control group was treated with isotretinoin erythromycin gel,and the study group was treated with isotretinoin capsule intermittent therapy com-bined with isotretinoin erythromycin gel.The clinical efficacy,skin physiological indexes and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 94.19%,which was higher than 84.88%of the control group,the difference was statistically significant(P<0.05);after treatment,the pH value of the study group was lower than that of the control group,the skin oil content was less than that of the control group,and the water content of the stratum corneum was more than that of the control group,and the differences between the two groups were statistically signifi-cant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Isotretinoin capsule intermittent therapy combined with isotretinoin erythromycin gel in the treatment of moder-ate to severe acne can improve the clinical efficacy and skin physiological indexes,with high safety.
Moderate to severe acneIsotretinoin capsule intermittent therapyIsotretinoin erythromycin gel
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