Effect of Taohong Siwu Decoction Combined with Acupuncture and Moxibustion on Inflammatory Response and Hemorheology in Patients with Knee Osteoarthritis
Objective To investigate the application effect of Taohong Siwu Decoction combined with acupuncture in patients with knee osteoarthritis(KOA).Methods 110 patients with KOA admitted to Tongren Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were selected as the study objects and divided into a control group and an observation group by random number table method,with 55 cases in each group.The control group was treated with acupuncture and moxibustion,and the observation group was treated with Taohong Siwu Decoction on the basis of control group.The clinical efficacy,knee function,inflammatory response,hemorheology and safety of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,each dimension and total score of the osteoarthritis index scale in the observation group were(16.49±1.85)points,(2.68±0.46)points,(0.67±0.13)points and(19.84±1.58)points,respectively,which were lower than(22.63±2.89)points,(3.71±0.53)points,(1.04±0.22)points and(27.38±2.68)points in the control group,the differences between the two groups were statistically significant(P＜0.05).After treatment,interleukin-6,tumor necrosis factor-α and interleukin-1β in the observation group were(48.13±4.35)ng/L,(17.25±1.45)pg/mL and(9.21±1.15)pg/mL,respectively,which were lower than(55.35±5.24)ng/L,(21.43±2.58)pg/mL and(11.73±1.29)pg/mL in the control group,the differences between the two groups were statistically significant(P＜0.05).After treatment,whole blood high tangential viscosity,plasma viscosity,whole blood low tangential viscosity and erythrocyte sedimentation rate in the observation group were(3.54±0.56)mPa·s,(1.41±0.23)mPa·s,(8.19±1.22)mPa·s,(6.82±1.13)mm/h,respectively,which were lower than(4.68±0.75)mPa·s,(1.65±0.31)mPa·s,(10.34±1.39)mPa·s,(8.41±1.18)mm/h in the control group,the differences between the two groups were statistically significant(P＜0.05).There was no adverse events occurred between the two groups.Conclusion Taohong Siwu Decoction combined with acupuncture and moxibustion can improve the efficacy of KOA treatment,reduce local inflammatory response,correct the abnormal hemorheology,and accelerate the recovery of knee joint function.
Knee osteoarthritisTaohong Siwu DecoctionAcupuncture and moxibustionInflammatory responseHemorheology
NETL
NSTL
万方数据
