无抽搐电休克结合喹硫平治疗双相情感障碍躁狂发作的疗效及对患者躁狂症状、认知功能的影响
Efficacy of Non Convulsive Electroconvulsive Therapy Combined with Quetiapine in the Treatment of Bipolar Disorder Manic Episodes and Its Impact on Manic Symptoms and Cognitive Function in Patients
刘锡亮 1姜丽丽 2王欣 1李钰1
作者信息
- 1. 青岛市精神卫生中心特检科,山东青岛 266000
- 2. 青岛大学附属青岛市中心医院、青岛市肿瘤医院肿瘤科,山东青岛 266000
- 折叠
摘要
目的 探究无抽搐电休克结合喹硫平治疗双相情感障碍(BPD)躁狂发作的疗效及对患者躁狂症状、认知功能的影响.方法 选择 2021 年 1 月—2023 年 6 月青岛大学附属青岛市中心医院收治的 60 例BPD患者为研究对象,按随机数字表法将其分为对照组和观察组,每组30 例.两组患者均给予常规治疗支持,对照组给予富马酸喹硫平片治疗,观察组给予富马酸喹硫平片和无抽搐电休克治疗.对比两组患者的临床疗效、躁狂症状和认知功能.结果 治疗后,观察组治疗总有效率、威斯康星卡片分类测验评分、持续操作测验评分、言语记忆测验评分均高于对照组,Bech-Rafaelsen躁狂量表评分低于对照组,组间差异有统计学意义(P＜0.05).结论 无抽搐电休克结合喹硫平治疗BPD患者有助于其躁狂症状减轻,可提高认知能力和临床疗效.
Abstract
Objective To investigate the efficacy of non convulsive electroconvulsive therapy combined with quetiapine in the treatment of manic episodes in bipolar disorder(BPD),and its impact on manic symptoms and cognitive function in patients.Methods Selecting 60 BPD patients admitted to Qingdao Central Hospital Affiliated to Qingdao University from January 2021 to June 2023 as the research subjects,divided into a control group and an observation group using a random number table method,with 30 cases in each group.Both groups of patients received routine treatment support.The control group received treatment with quetiapine fumarate tablets,while the observation group received treatment with quetiapine fumarate tablets and non convulsive electroconvulsive therapy.Compare the clinical efficacy,manic symptoms,and cognitive function between two groups of patients.Results After treatment,showed that the total effective rate,Wisconsin Card Sorting Test score,curricular practical training score,and Hopkins verbal learning test score in the observation group were higher than those in the control group;The score of the Bech-Rafaelsen Mania Rating Scal was lower than that of the control group,the difference between groups is statistically significant(P＜0.05).Conclusion The combination of non convulsive electroconvulsive therapy and quetiapine in the treatment of BPD patients can help alleviate manic symptoms,can improve cognitive ability and clinical efficacy.
关键词
双相情感障碍/躁狂发作/无抽搐电休克/喹硫平/临床疗效/躁狂症状/认知功能Key words
Bipolar disorder/Manic episodes/Non convulsive electroconvulsive therapy/Quetiapine/Clinical efficacy/Manic symptoms/Cognitive function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据