Effect of Mild Hypothermia Combined with Minimally Invasive Neuroendoscopic Surgery on Neurological Function and Prognosis of Patients with Hypertensive Intracerebral Hemorrhage
Objective To investigate the effect of mild hypothermia combined with minimally invasive neuroendoscopic surgery on neurological function and prognosis of patients with hypertensive intracerebral hemorrhage(HICH).Methods 70 patients with HICH treated in Nanchong Central Hospital of Sichuan Province from July 2021 to May 2023 were selected as the study objects and were divided into a control group and an observation group according to random number table method,with 35 cases in each group.The control group was treated with minimally invasive neuroendoscopic surgery,and the observation group was treated with mild hypothermia on this basis.3 months after surgery,the neurological function,daily activity ability,prognosis,serum inflammatory factor levels and quality of life of the two groups were compared.Results 3 months after surgery,the National Institutes of Health Stroke Scale score in the observation group was(10.26±1.27)points,which was lower than(11.87±1.34)points of the control group,while the Barthel Index score and Glasgow Outcome Scale score were(80.41±5.58)points and(4.08±0.43)points,respectively,which were higher than(73.21±5.24)points and(3.45±0.32)points in the control group,and the differences between the groups were statistically significant(P＜0.05).3 months after surgery,the levels of hypersensitive C-reactive protein,interleukin-6 and tumor necrosis factor-α in the observation group were(9.62±1.15)mg/L,(23.58±2.45)ng/L and(36.24±3.25)ng/L,respectively,which were lower than(12.04±1.27)mg/L,(30.34±3.45)ng/L and(42.47±4.36)ng/L in the control group,and the differences between the groups were statistically significant(P＜0.05).3 months after surgery,the scores of the physical,psychological,social and environmental fields in the World Health Organization Quality of Life-BREF scale of the observation group were(85.41±5.41)points,(86.34±5.39)points,(87.04±5.46)points and(88.37±5.39)points respectively,which were higher than(78.96±5.32)points,(79.05±5.33)points,(79.35±5.36)points,(80.41±5.26)points of the control group,and the differences between the groups were statistically significant(P＜0.05).Conclusion Mild hypothermia combined with minimally invasive neuroendoscopic surgery can improve the therapeutic effect of HICH,accelerate the recovery of neurological function,reduce the brain inflammation injury,and better improve the prognosis and quality of life of patients.
Hypertensive intracerebral hemorrhageMild hypothermia therapyMinimally invasive neuroendoscopic surgeryNeurological function
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