Effect of Trimetazidine Combined with External Counterpulsation in Elderly Patients with Chronic Heart Failure
Objective To investigate the effect of trimetazidine combined with external counterpulsation in elderly patients with chronic heart failure.Methods A total of 112 elderly patients with chronic heart failure admitted to the hospital from April 2022 to April 2023 were selected as the study objects,and divided into a control group and an observation group according to random number table method,with 56 cases in each group.The control group was treated with trimetazidine hydrochloride tablets,and the observation group was combined with external counterpulsation therapy on the basis of the control group.The clinical efficacy,cardiac function index,vascular endothelial function and quality of life between the two groups were compared.Results After 7 weeks of treatment,the total effective rate of the observation group was 96.43%,which was higher than 76.79%of the control group,the difference was statistically significant(P＜0.05).Left ventricular end-systolic diameter and left ventricular end-diastolic diameter in the observation group were shorter than those in control group,and left ventricular ejection fraction was higher than that in control group,and the differences were statistically significant(P＜0.05).The NMD and FMD of brachial artery in observation group were higher than those in control group,and human endothelin-1 was lower than that in control group,and the differences were statistically significant(P＜0.05).Lee's heart failure scores and Minnesota Heart Failure Quality of Life scale scores in the observation group were lower than those in the control group,and the differences between groups were statistically significant(P＜0.05).Conclusion The application of trimetazidine combined with external counterpulsation in elderly patients with chronic heart failure has significant efficacy,can improve the cardiac function and vascular endothelial function of patients,and is conducive to the improvement of their quality of life,and has safety.
Chronic heart failureAgedTrimetazidineExternal counterpulsationCardiac functionVascular endothelial function
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