The Effects of Ezetimibe Combined with Trimetazidine on Carotid Plaque Properties,Cardiac Function and Inflammatory Factors in Elderly Patients with Coronary Heart Disease
Objective To explore the effects of ezetimibe combined with trimetazidine on carotid plaque properties,cardiac function and inflammatory factors in elderly patients with coronary heart disease(CHD).Methods 82 elderly CHD patients admitted to the hospital from January 2020 to January 2023 were selected as the research subjects,divided into a control group and an observation group using a random number table method,with 41 cases in each group.The control group was treated with trimetazidine,and the observation group received treatment with ezetimibe on the basis of the control group.The clinical efficacy,intima-media thickness(IMT),plaque thickness(PT),carotid artery internal diameter and number of soft plaques,left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and adverse reactions.Results The total effective rate in the observation group was higher than that in the control group the difference was statistically significant(P＜0.05).Before treatment,comparison of properties,cardiac function,and inflammatory factors between two groups of carotid artery plaques,there was no statistically significant difference between groups(P＞0.05).After treatment,the IMT and PT of the two groups were thinner than those before treatment,the carotid artery diameter was shorter than that before treatment,and the number of soft plaques was less than that before treatment,the IMT and PT of the observation group were thinner than those of the control group,the carotid artery diameter was shorter than that of the control group,and the number of soft plaques was less than that of the control group.the difference was statistically significant(P＜0.05).After treatment,LVESD and LVEDD in both groups were shorter than before treatment,and the observation group was shorter than the control group,two groups of LVEF were higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant(P＜0.05).After treatment,two groups of hs-CRP,IL-6,and TNF-α levels were all lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).Comparison of incidence rates of adverse reactions between two groups,there was no statistically significant difference between groups(P＞0.05).Conclusion Ezetimibe combined with trimetazidine is effective in the treatment of elderly CHD patients,which can effectively improve the properties of carotid plaque,improve cardiac function and reduce the level of inflammatory factors,and is relatively safe.
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