The Effect of Nicorandil Combined with Tegrelor on Perioperative Coronary Microcirculation Disorders in Patients with Acute ST Segment Elevation Myocardial Infarction Undergoing PCI Treatment
Objective To analyze the effect of nicorandil combined with ticagrelor on patients with acute ST segment elevation myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Methods 70 patients with STEMI undergoing PCI admitted to Chifeng Hospital from September 2020 to September 2023 were selected as the study objects and randomly divided into a control group and an observation group,with 35 patients in each group,using a random number table method.The control group received treatment with ticagrelor,while the observation group received treatment with nicorandil on the basis of the control group.Compare perioperative coronary microcirculation indicators,myocardial injury markers,cardiac function,and adverse reactions between two groups.Results After treatment,the blood flow velocity in the observation group was faster than that in the control group,and the cross-sectional area of capillaries and myocardial blood flow were larger than those in the control group,and the differences between the groups were statistically significant(P＜0.05).After treatment,the isoenzyme of creatine kinase in the observation group was(16.38±1.25)U/L,cardiac troponin I was(0.11±0.01)ng/mL,and myoglobin was(54.29±3.29)ng/mL,which were lower than(22.29±1.76)U/L,(0.21±0.02)ng/mL,and(63.35±4.18)ng/mL in the control group,with statistically significant differences between the groups(P＜0.05).After treatment,the left ventricular end diastolic diameter in the observation group was(39.87±3.61)mm,and the left ventricular end systolic diameter was(40.61±3.71)mm,which were shorter than the control group's(43.40±4.23)mm and(46.42±5.29)mm,respectively,and the left ventricular ejection fraction was(53.72±6.53)%,which was higher than the control group's(48.36±5.71)%,and the differences between the groups were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Nicorandil combined with ticagrelor can improve perioperative coronary microcirculation,alleviate myocardial injury,and enhance cardiac function in STEMI patients undergoing PCI.
Acute ST segment elevation myocardial infarctionPercutaneous coronary intervention treatmentAdverse reactions
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