Effect of Furosemide,Iosorbide Mononitrate and Sodium Nitroprusside in the Clinical Treatment of Patients with Rheumatic Heart Disease Complicated with Heart Failure
Objective To investigate the clinical effect of furosemide combined with isosorbide mononitrate and sodium nitroprusside in the treatment of patients with rheumatic heart disease complicated with heart failure.Methods From February 2022 to May 2023,80 patients with rheumatic heart disease complicated with heart failure admitted to the Second People's Hospital of Yuncheng County were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 40 cases in each group.The control group was treated with isosorbide mononitrate and sodium nitroprusside,and the observation group was treated with furosemide on this basis.The clinical efficacy,cardiac function indexes,myocardial injury indexes,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the ventricular end-systolic volume and ventricular end-diastolic volume of the two groups were lower than those before treatment,and the levels of pentraxin and N-terminal pro-brain natriuretic peptide were lower than those before treatment,and the ventricular end-systolic volume and ventricular end-diastolic volume of the observation group were lower than those of the control group,and the levels of pentraxin and N-terminal pro-brain natriuretic peptide were lower than those of the control group.The differences were statistically significant(P＜0.05).The left ventricular ejection fraction of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion The combination of furosemide,isosorbide mononitrate and sodium nitroprusside is beneficial to improve the clinical efficacy of patients with rheumatic heart disease complicated with heart failure,reduce myocardial injury,improve cardiac function,and has good safety.
Rheumatic heart diseaseHeart failureFurosemideIsosorbide mononitrateSodium nitroprussideClinical efficacyCardiac function
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