The Efficacy and Safety of Nasal Irrigation Combined with Budesonide Nasal Spray Assisted Endoscopic Sinus Surgery in the Treatment of Chronic Sinusitis with Nasal Polyps
Objective To investigate the efficacy and safety of nasal irrigation combined with budesonide nasal spray in the treatment of chronic sinusitis with nasal polyps(CRSwNP).Methods A total of 86 patients with CRSwNP admitted to Jinxiang County People's Hospital from September 2021 to September 2023 were selected as the study objects,and the subjects were divided into a control group and an observation group according to random number table method,with 43 cases in each group.All patients underwent nasal endoscopic surgery,the control group was given budesonide nasal spray after surgery,and the observation group was given nasal irrigation based on the control group.The nasal ventilation function,mucous cilia clearance function,inflammatory factor levels and adverse reactions were compared between the two groups.Results At 8 weeks after surgery,the nasal volume and the minimum cross-sectional area of the nasal cavity in the observation group were(15.71±2.83)cm3 and(0.69±0.15)cm2,both of which were greater than(13.95±2.15)cm3 and(0.56±0.11)cm2 in the control group,and the distance from the minimum cross section of the nasal cavity to the anterior nostril was(1.34±0.10)cm,the clearance time of saccharin was(27.34±2.15)min,which was shorter than(1.57±0.15)cm and(30.21±2.95)min of the control group,the clearance speed of mucocilia was(5.23±0.71)mm/min,which was faster than(4.49±0.67)mm/min of the control group,the clearance rate of mucocilia was(61.83±8.67)%,higher than(55.79±7.21)%of the control group,interleukin-6 was(5.31±0.97)pg/mL,interleukin-8 was(276.53±14.35)ng/L,and tumor necrosis factor-α was(1.24±0.26)ng/mL,these levels were lower than(10.25±2.01)pg/mL,(325.71±18.96)ng/L and(2.70±0.41)ng/mL in the control group,with statistical significance between the two groups(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Nasal irrigation and budesonide nasal spray assisted endoscopic sinus surgery can improve nasal ventilation and nasal mucociliary clearance in patients with CRSwNP,and can control inflammatory reaction without serious adverse reactions.
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