Effect of the Combination Therapy of Allyl Estradiol and Progesterone on the Time of Symptom Relief and the Outcome of Fetal Preservation in Patients with Threatened Miscarriage
Objective To explore the effect of the combination therapy of allyl estradiol and progesterone on the time of symptom relief and the outcome of fetal preservation in patients with threatened miscarriage.Methods 78 patients with threatened abortion admitted to our hospital from April 2021 to September 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 39 cases in each group.Both groups of patients were given appropriate rest,reduce the amount of activity,maintain adequate nutrition,calm mood and other general treatment.The control group was treated with allyl estradiol tablets on the basis of general treatment,and the observation group was treated with progesterone injection on the basis of control group.Symptom remission time,outcome of fetal preservation,sex hormone indexes and adverse reactions were compared between the two groups.Results The time of hemostasis and relief of lumbar acid and abdominal pain in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P＜0.05).The pregnancy to extend the time of the observation group was longer than that of the control group,and the fetal preservation rate was higher than that of the control group,with statistical significance(P＜0.05).After 7 days of treatment,the levels of estradiol,progesterone and human chorionic gonadotropin in the observation group were(1 120.45±110.39)pg/mL,(89.64±7.13)nmol/L and(8 861.20±886.48)U/mL,respectively,which were higher than those in the control group,with statistical significance(P＜0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of allyl estradiol and progesterone in the treatment of threatened miscarriage patients is helpful in alleviating clinical symptoms,improving sex hormone indicators,enhancing immune function,and improving outcome of fetal preservation.It is also safe and worthy of promotion.
Threatened miscarriageAllyl estradiolProgesteroneClinical symptomsOutcome of fetal preservation
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