Effect of Ambroxol Hydrochloride Combined with Bronchoscopic Alveolar Lavage on the Improvement Time of Symptoms and Inflammatory Response in Patients with Severe Pneumonia and Atelectasis
Objective To explore the application effect of ambroxol hydrochloride combined with bronchoscopic alveolar lavage in patients with severe pneumonia and atelectasis.Methods 60 patients with severe pneumonia and atelectasis admitted to our hospital from January 2023 to September 2023 were selected as the research objects,and were divided into a control group and an observation group according to the random number table method,with 30 cases in each group.The control group was treated with bronchoscopic alveolar lavage,and the observation group was treated with ambroxol hydrochloride on this basis for two weeks.The inflammatory response,symptom improvement time,lung function index and blood gas index were compared between the two groups.Results After treatment,the levels of Interleukin-6,C-reactive protein,procalcitonin levels in the observation group were(47.36±4.33)pg/mL,(7.35±1.02)mg/L,(0.45±0.11)μg/L,respectively.The levels were lower than(52.43±4.96)pg/mL,(9.46±1.13)mg/L,(0.71±0.13)μg/L of the control group,the differences between the two groups were statistically significant(P＜0.05).The improvement time of body temperature,atelectasis,cough and lung moist rales in the observation group were(1.89±0.22)d,(7.52±1.12)d,(3.15±0.34)d and(4.05±0.49)d,respectively,which were shorter than(2.45±0.36)d,(9.63±1.25)d,(4.25±0.47)d,(5.14±1.02)d in the control group.The differences between the two groups were statistically significant(P＜0.05).forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC in the observation group were(3.25±0.39)L,(2.46±0.35)L,(75.69±5.82)%,respectively,which were greater than(2.89±0.35)L,(2.04±0.32)L,(70.59±5.73)%in the control group.The difference between the two groups were statistically significant(P＜0.05).The oxygen partial pressure of the observation group was(90.63±6.34)mmHg(1 mmHg=0.133 kPa),which was higher than(84.57±6.22)mmHg of the control group,and the partial pressure of carbon dioxide was(38.47±3.43)mmHg,which was lower than(42.46±4.02)mmHg of the control group,the differences between the two groups were statistically significant(P＜0.05).Conclusion Ambroxol hydrochloride combined with bronchoscopic alveolar lavage can accelerate the resolution of inflammation in patients with severe pneumonia and atelectasis,reduce pulmonary dysfunction,correct abnormal blood gas,and promote the disappearance of disease symptoms.
Severe pneumoniaAtelectasisAmbroxol hydrochlorideBronchoscopic alveolar lavageInflammatory response
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